Haplotype-based analysis: a summary of GAW16 Group 4 analysis.
Haplotype-based analysis: a summary of GAW16 Group 4 analysis.
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DOI：
10.1002/gepi.20468
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发表时间：
2009
影响因子：
2.1
通讯作者：
Deshmukh, Harshal
中科院分区：
文献类型：
--
作者：
Hauser, Elizabeth;Cremer, Nadine;Hein, Rebecca;Deshmukh, Harshal
In this summary paper, we describe the contributions included in the haplotype-based analysis group (Group 4) at the Genetic Analysis Workshop 16, which was held September 17-20, 2008. Our group applied a large number of haplotype-based methods in the context of genome-wide association studies. Two general approaches were applied: a two-stage approach that selected significant single-nucleotide polymorphisms and then created haplotypes and genome-wide analysis of smaller sets of single-nucleotide polymorphisms selected by sliding windows or estimating haplotype blocks. Genome-wide haplotype analyses performed in these ways were feasible. The presence of the very strong chromosome 6 association in the North American Rheumatoid Arthritis Consortium data was detected by every method, and additional analyses attempted to control for this strong result to allow detection of additional haplotype associations.
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DOI：
10.1126/science.1172257
发表时间：
2009-05-22
期刊：
Science (New York, N.Y.)
影响因子：
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通讯作者：
Williams SM
影响因子：
4.5
作者：
Spencer CC;Su Z;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D
DOI：
10.1073/pnas.0903103106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Hindorff, Lucia A.;Sethupathy, Praveen;Manolio, Teri A.
通讯作者：
Manolio, Teri A.
影响因子：
5.8
作者：
Abo, Ryan;Knight, Stacey;Camp, Nicola J.
通讯作者：
Camp, Nicola J.