Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development.

Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development.
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Sox 的分类:Sox 转录因子在神经嵴和颅面发育过程中的不同作用。

DOI:
10.3389/fphys.2020.606889
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发表时间:
2020
影响因子:
4
通讯作者:
LaBonne C
LaBonne C
中科院分区:
医学2区
文献类型:
--
作者:
Schock EN;LaBonne C

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Sox转录因子在发育过程中发挥着许多不同的作用,包括调节干细胞状态、指导分化以及影响局部染色质景观。在20种脊椎动物的Sox因子中,有几种在神经嵴的发育中发挥关键作用,神经嵴是脊椎动物的关键创新,随后形成神经嵴衍生的结构,包括颅面复合体。在此,我们回顾了神经嵴细胞形成过程中单个Sox因子的具体作用,并讨论了一些因子可能对神经嵴的演变至关重要。此外,我们还描述了Sox因子如何指导神经嵴细胞分化成不同的谱系,如黑素细胞,神经胶质细胞和软骨,并详细介绍了它们参与特定颅面结构的发展。最后,我们强调了几个与颅面表型相关的SOX。
Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Of the twenty vertebrate Sox factors, several play critical roles in the development the neural crest, a key vertebrate innovation, and the subsequent formation of neural crest-derived structures, including the craniofacial complex. Herein, we review the specific roles for individual Sox factors during neural crest cell formation and discuss how some factors may have been essential for the evolution of the neural crest. Additionally, we describe how Sox factors direct neural crest cell differentiation into diverse lineages such as melanocytes, glia, and cartilage and detail their involvement in the development of specific craniofacial structures. Finally, we highlight several SOXopathies associated with craniofacial phenotypes.
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发表时间: 2002-11-01
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