The Tinkerbell (Tink) Mutation Identifies the Dual-Specificity MAPK Phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a Novel Regulator of Organ Size in Arabidopsis.
The Tinkerbell (Tink) Mutation Identifies the Dual-Specificity MAPK Phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a Novel Regulator of Organ Size in Arabidopsis.
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DOI：
10.1371/journal.pone.0131103
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lenhard M
中科院分区：
文献类型：
--
作者：
Johnson KL;Ramm S;Kappel C;Ward S;Leyser O;Sakamoto T;Kurata T;Bevan MW;Lenhard M
有丝分裂原激活的双特异性MAPK磷酸酶是MAPK信号通路中重要的负调控因子，参与植物体内许多重要的生理过程。在筛选器官尺寸减小的突变体时，我们在双特异性MAPK磷酸酶吲哚-3-丁酸反应5（IBR 5）的活性位点中发现了一个突变，由于其尺寸小，我们将其命名为tinkerbell（tink）。对tink突变体的分析表明，IBR 5是一种新的器官大小调节剂，可以改变花瓣和叶子的生长速度。IBR 5对器官大小和形状的调节作用独立于KLU生长调节途径。微阵列分析的tink/ibr 5 -6突变体确定了这种磷酸酶在雄配子体发育中的可能作用。我们发现IBR 5可能通过生长素和TCP生长调节途径影响花瓣的大小和形状。
Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) that we named tinkerbell (tink) due to its small size. Analysis of the tink mutant indicates that IBR5 acts as a novel regulator of organ size that changes the rate of growth in petals and leaves. Organ size and shape regulation by IBR5 acts independently of the KLU growth-regulatory pathway. Microarray analysis of tink/ibr5-6 mutants identified a likely role for this phosphatase in male gametophyte development. We show that IBR5 may influence the size and shape of petals through auxin and TCP growth regulatory pathways.
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