Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study.
Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study.
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DOI：
10.1002/hbm.25304
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发表时间：
2021-04-01
影响因子：
4.8
通讯作者：
Perez DL
中科院分区：
文献类型：
--
作者：
Sojka P;Diez I;Bareš M;Perez DL
在运动功能性神经系统疾病（mFND），内感受（一个结构的高度理论相关性，其病理生理学）和神经解剖学之间的关系尚未进行过研究。本研究比较了mFND患者与健康对照（HC）的白色物质特征，并研究了纤维束完整性与心脏内感受之间的相关性。基于体素的分析和纤维束成像定量了38例mFND患者和38例HC患者的各向异性分数（FA）。次要分析比较了功能性癫痫发作（FND‐seiz; n = 21）或功能性运动障碍（n = 17）与HC。网络病变映射确定了牵连纤维束的灰质起源。组内mFND分析研究了FA，心跳跟踪准确性和内感受性特质预测误差之间的关系（内感受性准确性和自我报告的身体意识之间的差异）。结果进行了多重比较校正，所有的研究结果都调整了抑郁和特质焦虑。mFND和HC未显示任何组间内感受准确性或FA差异。然而，与HC相比，FND‐seiz亚组显示右侧束的完整性降低：极囊/下额枕束、弓状束、下纵束和丘脑/纹状体至枕叶皮质投射。这些改变主要起源于右颞顶交界处和颞下回。在mFND患者中，内感受准确性和内感受性状预测误差的个体差异与起源于丘脑、颞顶交界处、壳核和丘脑等区域的纤维束完整性相关。在这第一项研究中，研究了mFND中的脑内感受关系，内感受准确性和性状预测误差的个体差异映射到多模态整合相关的纤维束上。右侧边缘系统和联合束中断将FND-seiz与HC区分开来。在这第一项研究中，研究了mFND中的脑内感受关系，内感受准确性和性状预测误差的个体差异映射到多模态整合相关的纤维束上。右侧边缘系统和联合束中断将FND-seiz与HC区分开来。
In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel‐based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND‐seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within‐group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self‐reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between‐group interoceptive accuracy or FA differences. However, the FND‐seiz subgroup compared to HCs showed decreased integrity in right‐lateralized tracts: extreme capsule/inferior fronto‐occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain‐interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration‐related fiber bundles. Right‐lateralized limbic and associative tract disruptions distinguished FND‐seiz from HCs. In this first study investigating brain‐interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration‐related fiber bundles. Right‐lateralized limbic and associative tract disruptions distinguished FND‐seiz from HCs.
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