Non-genetic contributions of the sperm nucleus to embryonic development.
Non-genetic contributions of the sperm nucleus to embryonic development.
复制标题
DOI：
10.1038/aja.2010.75
复制
发表时间：
2011-01
影响因子：
2.9
通讯作者：
Ward, W. Steven
中科院分区：
文献类型：
--
作者：
Yamauchi, Yasuhiro;Shaman, Jeffrey A.;Ward, W. Steven
最近来自几个实验室的数据提供了证据，证明新受精的卵母细胞继承了来自精子染色质的表观遗传信号，这些信号是正常胚胎发育所必需的。为了本综述的目的，表观遗传术语用于描述从精子细胞传递到胚胎的所有类型的分子信息。至少有六种不同形式的表观遗传信息已经被确定为哺乳动物正常胚胎发生所必需的，或者有证据表明它可能这样做。这些是(1)DNA甲基化，(2)精子特异性组蛋白，(3)其他染色质相关蛋白，(4)核膜周围蛋白，(5)精子出生的rna，以及(6)由精子核基质组织的DNA环结构域。在设计用于ART的精子操作和冷冻保存方案时应考虑这些表观遗传信号，作为有效受精和随后胚胎发育的必要组成部分。
Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are (1) DNA methylation, (2) sperm specific histones, (3) other chromatin associated proteins, (4) the perinuclear theca proteins, (5) sperm born RNAs, and, the focus of this review, (6) the DNA loop Domain organization by the sperm nuclear matrix. These epigenetic signals should be considered when designing protocols for the manipulation and cryopreservation of spermatozoa for ART, as necessary components for effective fertilization and subsequent embryo development.
登录
查看更多内容
影响因子：
4
作者：
GETZENBERG, RH
通讯作者：
GETZENBERG, RH
影响因子：
56.9
作者：
Brewer, LR;Corzett, M;Balhorn, R
通讯作者：
Balhorn, R
影响因子：
9.2
作者：
Durrieu, F;Samejima, K;Earnshaw, WC
通讯作者：
Earnshaw, WC
影响因子：
4.8
作者：
CHOUDHARY, SK;WYKES, SM;KRAWETZ, SA
通讯作者：
KRAWETZ, SA
影响因子：
3.6
作者：
Codrington, Alexis M.;Hales, Barbara F.;Robaire, Bernard
通讯作者：
Robaire, Bernard