New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons.
New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons.
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新规则管理着核心核核核核中棘神经元中的突触可塑性。
DOI：
10.1111/ejn.12002
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Martin GE
中科院分区：
文献类型：
--
作者：
Ji X;Martin GE
延髓核是负责药物奖励和目标导向行为的前脑区域。长期以来，人们一直认为滥用药物通过长时间改变突触通信的强度来对行为施加成瘾特性。迄今为止，试图了解滥用药物和突触可塑性之间的关系依赖于高频长时程增强模型。我们研究了突触可塑性使用尖峰时间依赖性，刺激范式，反映更密切地在体内的核心NAcc中型多刺神经元和它们的传入放电模式。与其他大脑区域相比，相同的刺激范式诱发了双向长期可塑性。长时程增强（tLTP）的幅度随着动作电位（AP）和兴奋性突触后电位（EPSP）之间的延迟和频率而变化，而长时程抑制（tLTD）的幅度保持不变。我们发现tLTP依赖于NMDA受体，而tLTD依赖于动作电位。重要的是，在tLTP和tLTD期间动员的细胞内钙信号通路是不同的。因此，钙诱导的钙释放是tLTD而不是tLTP的基础。最后，我们发现，发射模式的一个子集的MSN强烈抑制多巴胺受体激动剂。令人惊讶的是，这些神经元只与tLTP相关，而与tLTD无关。总之，这些数据表明存在两个具有不同性质的MSN亚组，每个亚组都显示出独特的突触可塑性。
The nucleus accumbens is a forebrain region responsible for drug reward and goal directed behaviors. It has long been believed that drugs of abuse exert their addictive properties on behavior by altering the strength of synaptic communication over long periods of time. To date, attempts at understanding the relationship between drugs of abuse and synaptic plasticity have relied on the high-frequency long-term potentiation model of. We examined synaptic plasticity using spike-timing-dependent plasticity, a stimulation paradigm that reflects more closely in vivo firing patterns of core NAcc medium spiny neurons and their afferents. In contrast to other brain regions, the same stimulation paradigm evoked bidirectional long-term plasticity. Long-term potentiation (tLTP) magnitude changed with delay between action potentials (APs) and excitatory post-synaptic potentials (EPSPs), and frequency, while that of long-term depression (tLTD) remained unchanged. We showed that tLTP depended on NMDA receptors, whereas tLTD relied on action potentials. Importantly, intracellular calcium signaling pathways mobilized during tLTP and tLTD were different. Thus, calcium-induced calcium release underlies tLTD but not tLTP. Finally, we found that the firing pattern of a subset of MSNs was strongly inhibited by dopamine receptor agonists. Surprisingly, these neurons were exclusively associated with tLTP but not with tLTD. Taken together, these data point to the existence of two subgroups of MSNs with distinct properties, each displaying unique abilities to undergo synaptic plasticity.
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