Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
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晚期卵巢癌患者诱导化疗后淋巴细胞减少与手术切除不完全相关
DOI：
10.1007/s10147-018-1374-4
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发表时间：
2018
影响因子：
3.3
通讯作者：
Yasugi Toshiharu
中科院分区：
文献类型：
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作者：
Yoshino Yasunori;Taguchi Ayumi;Takao Maki;Kashiyama Tomoko;Furusawa Akiko;Uno Masaya;Okada Satoshi;Kino Nao;Yasugi Toshiharu
淋巴细胞减少与各种癌症患者预后不良有关，但对卵巢上皮癌患者诱导化疗(IC)后淋巴细胞减少对预后的影响知之甚少。本研究探讨晚期卵巢癌患者IC治疗前后淋巴细胞减少的预后意义。方法回顾2009-2017年间我所收治的68例III/IV期卵巢癌、输卵管癌或腹膜癌患者IC治疗前后的临床资料。我们评估了IC前和IC后的炎症标志物，包括淋巴细胞计数，与几种肿瘤预后的关系，如实施间隔去胆总术、完全切除、无进展生存期(PFS)和总生存期(OS)。结果与IC前相比，IC后淋巴细胞计数显著升高(P= 0.009)。IC前有27例(40%)患者出现淋巴细胞减少，而IC后仅有16例(24%)患者出现淋巴细胞减少(P= 0.020)。在几种炎症标志物中，只有IC术后淋巴细胞减少与不完全切除的结果显著相关(P= 0.012)。此外，IC后淋巴细胞减少与术后不良预后显著相关(LOG-RANK检验，P= 0.009)，而IC前淋巴细胞减少与PFS和OS均无关。结论IC后淋巴细胞减少可能预示着晚期卵巢癌患者手术切除不彻底和预后不良。
BackgroundLymphopenia is associated with poor outcomes in patients with various cancers, but little is known about the prognostic impact of lymphopenia in patients with epithelial ovarian cancer (EOC) after induction chemotherapy (IC). This study investigated the prognostic significance of pre- and post-IC lymphopenia in patients with advanced EOC.MethodsWe reviewed medical records of 68 patients with stage III/IV ovarian, fallopian tube, or peritoneal cancer treated with IC at our institution between 2009 and 2017. We assessed the associations of pre- and post-IC inflammatory markers, including lymphocyte counts, with several oncological outcomes, such as the implementation of interval debulking surgery (IDS), complete resection, progression-free survival (PFS), and overall survival (OS).ResultsLymphocyte counts increased significantly post-IC compared with the pre-IC values (P= 0.009). Pre-IC lymphopenia was observed in 27 patients (40%), whereas only 16 patients (24%) displayed lymphopenia post-IC (P= 0.020). Among several inflammatory markers, only post-IC lymphopenia was significantly associated with incomplete resection outcome during IDS (P= 0.012). Moreover, post-IC lymphopenia was significantly associated with poor PFS (log-rank test,P= 0.009), whereas pre-IC lymphopenia was associated with neither PFS nor OS.ConclusionsPost-IC lymphopenia may predict incomplete resection during IDS and poor prognosis in patients with advanced EOC.
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影响因子：
--
作者：
Kim YJ;Lee I;Chung YS;Nam E;Kim S;Kim SW;Kim YT;Lee JY
通讯作者：
Lee JY
DOI：
10.1097/igc.0000000000001233
发表时间：
2018-06-01
影响因子：
4.8
作者：
Marchetti, Claudia;Romito, Alessia;Panici, Pierluigi Benedetti
通讯作者：
Panici, Pierluigi Benedetti
影响因子：
11.2
作者：
Ray-Coquard I;Cropet C;Van Glabbeke M;Sebban C;Le Cesne A;Judson I;Tredan O;Verweij J;Biron P;Labidi I;Guastalla JP;Bachelot T;Perol D;Chabaud S;Hogendoorn PC;Cassier P;Dufresne A;Blay JY;European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
通讯作者：
European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
影响因子：
4.7
作者：
Williams KA;Labidi-Galy SI;Terry KL;Vitonis AF;Welch WR;Goodman A;Cramer DW
通讯作者：
Cramer DW
DOI：
10.1097/igc.0000000000000924
发表时间：
2017-03-01
影响因子：
4.8
作者：
Baek, Min-Hyun;Lee, Shin-Wha;Nam, Joo-Hyun
通讯作者：
Nam, Joo-Hyun