Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer.
Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer.
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DOI：
10.1016/j.ygyno.2014.01.026
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发表时间：
2014-03
影响因子：
4.7
通讯作者：
Cramer DW
中科院分区：
文献类型：
--
作者：
Williams KA;Labidi-Galy SI;Terry KL;Vitonis AF;Welch WR;Goodman A;Cramer DW
目的探讨卵巢癌患者外周血中中性粒细胞/淋巴细胞比率(NLR)的变化。记录了波士顿两家医院519名卵巢癌患者的治疗前白细胞计数和CA125水平、肿瘤特征和问卷数据。计数进行对数转换，并通过方差分析和广义线性模型评估肿瘤特征和流行病学变量对计数的影响。使用COX比例风险模型评估对总体生存的影响。较大的NLR与较高的肿瘤分期和分级、存在腹水和双侧疾病相关，并与危险因素相关，包括犹太民族、较高的身高、更多的排卵周期、绝经前妇女的癌症家族史和所有妇女使用滑石粉。CA125与中性粒细胞计数、单核细胞计数、中性粒细胞受体呈正相关，与淋巴细胞计数呈负相关。在多变量调整分析中，高NLR预示着较差的存活率，而高淋巴细胞计数则预示着较好的存活率。治疗前NLR升高标志着更具侵袭性的疾病，并与卵巢癌的风险因素相关。CA125与中性粒细胞直接相关，这可能反映了肿瘤分泌CA125和中性粒细胞生长因子。CA125与淋巴细胞呈负相关，这可能反映了某些中性粒细胞因子诱导淋巴细胞减少的能力和/或CA125与淋巴细胞结合的能力，从而将CA125从血清池中移除。NLR、CA125和流行病学因素之间的联系可能为卵巢癌的发病机制和进展提供新的线索。
To investigate the neutrophil-to-lymphocyte ratio (NLR) from peripheral blood, a general measure of inflammation, in ovarian cancer. White cell counts and CA125 levels before treatment, tumor features, and questionnaire data on 519 women with ovarian cancer at two Boston hospitals were recorded. Counts were log-transformed and effects on these by tumor features and epidemiologic variables assessed by analysis of variance and generalized linear models. Cox proportional hazards models were used to assess effects on overall survival. Greater NLR was associated with higher tumor stage and grade, presence of ascites, and bilateral disease and correlated with risk factors including Jewish ethnicity, taller height, more ovulatory cycles, and family history of cancer in premenopausal women and talc use in all women. CA125 was positively correlated with neutrophil count, monocyte count, and NLR and inversely correlated with lymphocyte count. In a multivariate adjusted analysis, high NLR predicted poorer survival and high lymphocyte count better survival. An elevated NLR before treatment signals more aggressive disease and correlates with risk factors for ovarian cancer. CA125 directly correlates with neutrophils which may reflect secretion of both CA125 and neutrophilic growth factors by the tumor. CA125 inversely correlates with lymphocytes which may reflect the ability of some neutrophilic factors to induce lymphopenia and/or binding of CA125 to lymphocytes removing CA125 from the serum pool. Links between NLR, CA125, and epidemiologic factors may provide new clues about the pathogenesis and progression of ovarian cancer.
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影响因子：
7.4
作者：
Milne K;Alexander C;Webb JR;Sun W;Dillon K;Kalloger SE;Gilks CB;Clarke B;Köbel M;Nelson BH
通讯作者：
Nelson BH
影响因子：
51.1
作者：
Green, Jane;Cairns, Benjamin J.;Casabonne, Delphine;Wright, F. Lucy;Reeves, Gillian;Beral, Valerie
通讯作者：
Beral, Valerie
DOI：
10.1016/0090-1229(88)90022-0
发表时间：
1988-09-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
DEPAOLI, P;BATTISTIN, S;SANTINI, GF
通讯作者：
SANTINI, GF
影响因子：
3.6
作者：
Parrott, JA;Kim, G;Skinner, MK
通讯作者：
Skinner, MK
影响因子：
3.8
作者：
Cramer, DW;Titus-Ernstoff, L;Finn, OJ
通讯作者：
Finn, OJ