The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.
The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.
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DOI：
10.1371/journal.pbio.0020328
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发表时间：
2004-10
期刊：
影响因子：
9.8
通讯作者：
Losick R
中科院分区：
文献类型：
--
作者：
Eichenberger P;Fujita M;Jensen ST;Conlon EM;Rudner DZ;Wang ST;Ferguson C;Haga K;Sato T;Liu JS;Losick R
枯草芽孢杆菌在孢子中的不对称分裂会产生一个经历5-H的分化程序的母细胞。 383个基因的激活和表达在262个基因上，包括用于Gerr和Spoiiid的基因。接下来，σk的外观激活了75个基因，包括该DNA结合蛋白。有证据表明，反射和激活有助于适当的形态发生。前循环产生基因转录的成功脉冲。
枯草芽孢杆菌孢子孢子的全面基因组分析揭示了一个协调的基因激活和表达程序，其中涉及383个基因
Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: σE, σK, GerE, GerR, and SpoIIID. The program consists of the activation and repression of 383 genes. The σE factor turns on 262 genes, including those for GerR and SpoIIID. These DNA-binding proteins downregulate almost half of the genes in the σE regulon. In addition, SpoIIID turns on ten genes, including genes involved in the appearance of σK . Next, σK activates 75 additional genes, including that for GerE. This DNA-binding protein, in turn, represses half of the genes that had been activated by σK while switching on a final set of 36 genes. Evidence is presented that repression and activation contribute to proper morphogenesis. The program of gene expression is driven forward by its hierarchical organization and by the repressive effects of the DNA-binding proteins. The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation. A comprehensive genomic analysis of sporulation in Bacillus subtilis reveals a coordinated program of gene activation and repression, which involves 383 genes
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影响因子：
5.6
作者：
CUTTING, S;PANZER, S;LOSICK, R
通讯作者：
LOSICK, R
影响因子：
4.8
作者：
Graham, DE;Xu, HM;White, RH
通讯作者：
White, RH
影响因子：
3.2
作者：
Britton, RA;Eichenberger, P;Grossman, AD
通讯作者：
Grossman, AD
影响因子：
3.2
作者：
BALDUS, JM;GREEN, BD;MORAN, CP
通讯作者：
MORAN, CP
影响因子：
3.2
作者：
BONSEN, PPM;SPUDICH, JA;KORNBERG, A
通讯作者：
KORNBERG, A