Immunoexpression of Ki67, p53 and cyclin D1 in osteosarcomas.
Immunoexpression of Ki67, p53 and cyclin D1 in osteosarcomas.
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DOI：
10.47162/rjme.62.3.11
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发表时间：
2021-07
影响因子：
1
通讯作者：
Stepan, Alex Emilian
中科院分区：
文献类型：
--
作者：
Niculescu, Stefan Adrian;Grecu, Dan Cristian;Simionescu, Cristiana Eugenia;Niculescu, Elena Carmen;Stepan, Mioara Desdemona;Stepan, Alex Emilian
骨组织的主要恶性肿瘤以骨肉瘤为代表，这是一种预后不佳、发展不可预测的肿瘤，通常具有侵袭性。细胞周期破坏是骨肉瘤发展过程中复杂的生物分子机制之一。在本研究中，我们分析了18例原始骨肉瘤中Ki67、p53和cyclin D1的免疫表达与病变临床病理预后参数的关系。结果显示病变以男性年轻患者为主，以股骨为部位，肿瘤多为成骨细胞型，肿瘤分级高，肿瘤大小< 8cm，肿瘤进展较晚。所有病例均出现反应，高免疫表达与成骨细胞/上皮样细胞类型（Ki67、cyclin D1、p53）、高级别（Ki67、cyclin D1）和晚期（Ki67、cyclin D1）相关。该研究揭示了所研究的免疫标志物表达的正线性关系，这表明它们在识别具有侵袭性进展潜力的病变方面是有用的。
The main malignant tumor of the bone tissue is represented by osteosarcoma, neoplasia with a reserved prognosis and an unpredictable evolution, often aggressive. Cell cycle disruption is one of the complex biomolecular mechanisms involved in the progression of osteosarcomas. In this study, we analyzed the immunoexpression of Ki67, p53 and cyclin D1 for 18 primitive osteosarcomas in relation to the clinicopathological prognosis parameters of the lesions. The results indicated the predominance of lesions in male young patients, with femoral location, most tumors being represented by the osteoblastic type, with high grade, size <8 cm and in advanced stages. Reactions were present in all cases, the high immunoexpression being associated with osteoblastic/epithelioid types (Ki67, cyclin D1, p53), high grade (Ki67, cyclin D1) and advanced stage (Ki67, cyclin D1). The study revealed a positive linear relation of the investigated immunomarkers expression, which indicates their usefulness in identifying lesions with aggressive progression potential.
影响因子：
2.9
作者：
Liu P;Wang M;Li L;Jin T
通讯作者：
Jin T