Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.
Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.
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DOI：
10.1161/jaha.121.025109
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发表时间：
2022-05-17
影响因子：
5.4
通讯作者：
Liew, Sook-Lei
中科院分区：
文献类型：
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作者：
Zavaliangos-Petropulu, Artemis;Lo, Bethany;Donnelly, Miranda R.;Schweighofer, Nicolas;Lohse, Keith;Jahanshad, Neda;Barisano, Giuseppe;Banaj, Nerisa;Borich, Michael R.;Boyd, Lara A.;Buetefisch, Cathrin M.;Byblow, Winston D.;Cassidy, Jessica M.;Charalambous, Charalambos C.;Conforto, Adriana B.;DiCarlo, Julie A.;Dula, Adrienne N.;Egorova-Brumley, Natalia;Etherton, Mark R.;Feng, Wuwei;Fercho, Kelene A.;Geranmayeh, Fatemeh;Hanlon, Colleen A.;Hayward, Kathryn S.;Hordacre, Brenton;Kautz, Steven A.;Khlif, Mohamed Salah;Kim, Hosung;Kuceyeski, Amy;Lin, David J.;Liu, Jingchun;Lotze, Martin;MacIntosh, Bradley J.;Margetis, John L.;Mohamed, Feroze B.;Piras, Fabrizio;Ramos-Murguialday, Ander;Revill, Kate P.;Roberts, Pamela S.;Robertson, Andrew D.;Schambra, Heidi M.;Seo, Na Jin;Shiroishi, Mark S.;Stinear, Cathy M.;Soekadar, Surjo R.;Spalletta, Gianfranco;Taga, Myriam;Tang, Wai Kwong;Thielman, Gregory T.;Vecchio, Daniela;Ward, Nick S.;Westlye, Lars T.;Werden, Emilio;Winstein, Carolee;Wittenberg, George F.;Wolf, Steven L.;Wong, Kristin A.;Yu, Chunshui;Brodtmann, Amy;Cramer, Steven C.;Thompson, Paul M.;Liew, Sook-Lei
中风后持续的感觉运动障碍会对生活质量产生负面影响。海马体易受卒中后继发性变性的影响，并参与感觉运动行为，但尚未在卒中后上肢感觉运动损伤的背景下进行广泛研究。我们研究了非损伤海马体积与慢性卒中患者上肢感觉运动障碍之间的关系，假设同侧损伤海马体积较小与更大的感觉运动障碍相关。来自ENIGMA（通过Meta分析增强神经成像遗传学）卒中恢复工作组18个研究队列的357名慢性卒中患者的脑横断面T1加权磁共振图像汇总。通过FMA‐UE （Fugl‐Meyer上肢评估）评估感觉运动障碍。采用稳健混合效应线性模型检验卒中后感觉运动损伤与海马体积之间的关系（同侧和对侧分别；Bonferroni校正，P<0.025），控制年龄、性别、病变体积和受损半球。在探索性分析中，我们测试了感觉运动损伤和性别相互作用，以及病变体积、感觉运动损伤和海马体积之间的关系。更严重的感觉运动损伤与同病灶海马体积显著相关（P=0.005; β=0.16），而与对照海马体积无关（P=0.96; β=0.003），与病灶体积和其他协变量无关（P=0.001; β=0.26）。与男性相比，女性感觉运动障碍逐渐加重，同侧海马体积（P=0.008; β= - 0.26）和对侧海马体积（P=0.006; β= - 0.27）较小。海马体积与病变大小（P<0.001; β= - 0.21）和感觉运动损伤程度（P=0.003; β= - 0.15）相关。目前的研究确定了慢性中风后感觉运动障碍与同侧海马体积之间的新联系，这种联系不是由病变大小引起的，可能在女性中更强。
Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Cross‐sectional T1‐weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta‐Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA‐UE (Fugl‐Meyer Assessment of Upper Extremity). Robust mixed‐effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni‐corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15). The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.
影响因子：
3.4
作者：
Etherton MR;Fotiadis P;Giese AK;Iglesias JE;Wu O;Rost NS
通讯作者：
Rost NS