White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke.
White Matter Hyperintensity Burden Is Associated With Hippocampal Subfield Volume in Stroke.
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DOI：
10.3389/fneur.2020.588883
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发表时间：
2020
影响因子：
3.4
通讯作者：
Rost NS
中科院分区：
文献类型：
--
作者：
Etherton MR;Fotiadis P;Giese AK;Iglesias JE;Wu O;Rost NS
推定血管源性白质高信号（WMH）是一种常见的脑血管疾病，也是脑卒中后认知功能障碍的重要危险因素。尽管存在这种普遍现象，但对于WMH是如何导致中风后认知功能障碍的还不是很清楚。初步研究结果表明，慢性脑卒中患者WMH体积的增加与海马总体积有关。然而，海马体是一个复杂的结构，具有不同的子区，这些子区在海马体回路的功能中起着不同的作用，并且对不同的大脑区域有独特的解剖投影。基于这些原因，对WMH与海马亚区体积之间关系的研究可能会进一步描述WMH是如何导致脑卒中后认知功能障碍的。在一项对中度/重度WMH负担的急性缺血性卒中患者的前瞻性研究中，我们评估了定量WMH负担与海马亚区体积之间的关系。患者在中风发作后2-5天内接受3T脑MRI检查。以半自动化的方式计算总WMH体积。在对侧半球测量平均皮质厚度和海马体积。使用自动化、高分辨率、离体计算图谱测量海马总体积和亚区体积。对海马总体积和亚区体积的预测因子进行线性回归分析。40例急性缺血性脑卒中伴中/重度白质高负荷患者纳入本分析。WMH中位容积为9.0 cm3。调整颅内容积和脑卒中偏侧性后，年龄（β =−3.7,P < 0.001）、高血压（β =−44.7,P = 0.04）、WMH体积（β =−0.89,P = 0.049）和平均皮质厚度（β = 286.2, P = 0.006）与海马总容积相关。在多变量分析中，年龄（β =−3.3,P < 0.001）和皮质厚度（β = 205.2, P = 0.028）仍然与海马总体积独立相关。在海马亚区体积预测因子的线性回归中，WMH体积增加与海马-杏仁核过渡区体积减少相关（β = - 0.04, P = 0.001）。这些发现表明，在缺血性卒中患者中，WMH负荷增加与海马-杏仁核过渡区选择性海马亚区变性有关。
White matter hyperintensities of presumed vascular origin (WMH) are a prevalent form of cerebral small-vessel disease and an important risk factor for post-stroke cognitive dysfunction. Despite this prevalence, it is not well understood how WMH contributes to post-stroke cognitive dysfunction. Preliminary findings suggest that increasing WMH volume is associated with total hippocampal volume in chronic stroke patients. The hippocampus, however, is a complex structure with distinct subfields that have varying roles in the function of the hippocampal circuitry and unique anatomical projections to different brain regions. For these reasons, an investigation into the relationship between WMH and hippocampal subfield volume may further delineate how WMH predispose to post-stroke cognitive dysfunction. In a prospective study of acute ischemic stroke patients with moderate/severe WMH burden, we assessed the relationship between quantitative WMH burden and hippocampal subfield volumes. Patients underwent a 3T MRI brain within 2–5 days of stroke onset. Total WMH volume was calculated in a semi-automated manner. Mean cortical thickness and hippocampal volumes were measured in the contralesional hemisphere. Total and subfield hippocampal volumes were measured using an automated, high-resolution, ex vivo computational atlas. Linear regression analyses were performed for predictors of total and subfield hippocampal volumes. Forty patients with acute ischemic stroke and moderate/severe white matter hyperintensity burden were included in this analysis. Median WMH volume was 9.0 cm3. Adjusting for intracranial volume and stroke laterality, age (β = −3.7, P < 0.001), hypertension (β = −44.7, P = 0.04), WMH volume (β = −0.89, P = 0.049), and mean cortical thickness (β = 286.2, P = 0.006) were associated with total hippocampal volume. In multivariable analysis, age (β = −3.3, P < 0.001) and cortical thickness (β = 205.2, P = 0.028) remained independently associated with total hippocampal volume. In linear regression for predictors of hippocampal subfield volume, increasing WMH volume was associated with decreased hippocampal-amygdala transition area volume (β = −0.04, P = 0.001). These finding suggest that in ischemic stroke patients, increased WMH burden is associated with selective hippocampal subfield degeneration in the hippocampal-amygdala transition area.
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影响因子：
11
作者：
Cao B;Passos IC;Mwangi B;Amaral-Silva H;Tannous J;Wu MJ;Zunta-Soares GB;Soares JC
通讯作者：
Soares JC
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
8.3
作者：
Etherton, Mark R.;Wu, Ona;Rost, Natalia S.
通讯作者：
Rost, Natalia S.
影响因子：
3.3
作者：
Fudge, J. L.;Decampo, D. M.;Becoats, K. T.
通讯作者：
Becoats, K. T.
影响因子：
6.7
作者：
Kebets, Valeria;Gregoire, Simone M.;Werring, David J.
通讯作者：
Werring, David J.