Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity.
Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity.
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DOI：
10.3389/fimmu.2020.02143
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发表时间：
2020
影响因子：
7.3
通讯作者：
Ikuta K
中科院分区：
文献类型：
--
作者：
Shimba A;Ikuta K
动物进化出昼夜节律以适应24小时的昼夜循环。昼夜节律是由大脑和外围的分子钟控制的，而分子钟是由时钟基因驱动的。昼夜节律通过神经和激素从大脑传播到周围。糖皮质激素（Glucocorticoids, GCs）是由肾上腺皮质在昼夜节律和应激的控制下产生的一类类固醇激素。GCs对免疫系统有积极和消极的影响。事实上，它们以其强大的抗炎和免疫抑制作用而闻名。内源性GCs抑制小鼠活性期炎症因子和趋化因子的表达，调节组织炎症的昼夜节律。此外，GCs诱导T细胞上IL-7R和CXCR4的节律性表达，支持T细胞维持和归巢到淋巴组织。时钟基因和肾上腺素能神经活动控制T细胞迁移和免疫反应。综上所述，昼夜节律因素塑造了先天免疫和适应性免疫的昼夜振荡。其中，GCs通过正、负两种作用参与先天免疫和适应性免疫的昼夜节律。
Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian rhythms are controlled by molecular clocks in the brain and periphery, which is driven by clock genes. The circadian rhythm is propagated from the brain to the periphery by nerves and hormones. Glucocorticoids (GCs) are a class of steroid hormones produced by the adrenal cortex under the control of the circadian rhythm and the stress. GCs have both positive and negative effects on the immune system. Indeed, they are well known for their strong anti-inflammatory and immunosuppressive effects. Endogenous GCs inhibit the expression of inflammatory cytokines and chemokines at the active phase of mice, regulating the circadian rhythm of tissue inflammation. In addition, GCs induce the rhythmic expression of IL-7R and CXCR4 on T cells, which supports T cell maintenance and homing to lymphoid tissues. Clock genes and adrenergic neural activity control the T cell migration and immune response. Taken together, circadian factors shape the diurnal oscillation of innate and adaptive immunity. Among them, GCs participate in the circadian rhythm of innate and adaptive immunity by positive and negative effects.
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影响因子：
82.9
作者：
通讯作者：
--
淋巴细胞昼夜节律的时钟控制淋巴结运输和适应性免疫反应。
影响因子：
32.4
作者：
Druzd D;Matveeva O;Ince L;Harrison U;He W;Schmal C;Herzel H;Tsang AH;Kawakami N;Leliavski A;Uhl O;Yao L;Sander LE;Chen CS;Kraus K;de Juan A;Hergenhan SM;Ehlers M;Koletzko B;Haas R;Solbach W;Oster H;Scheiermann C
通讯作者：
Scheiermann C
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
4.4
作者：
Jourdan, P;Vendrell, JP;Yssel, H
通讯作者：
Yssel, H
影响因子：
20.3
作者：
Bhattacharyya, Sandip;Brown, Diane E.;Muglia, Louis J.
通讯作者：
Muglia, Louis J.