The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.
The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.
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DOI：
10.1016/j.neuroimage.2010.01.094
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发表时间：
2010-11-15
期刊：
影响因子：
5.7
通讯作者：
Kates, Wendy R.
中科院分区：
文献类型：
--
作者：
Coman, Ioana L.;Gnirke, Matthew H.;Middleton, Frank A.;Antshel, Kevin M.;Fremont, Wanda;Higgins, Anne Marie;Shprintzen, Robert J.;Kates, Wendy R.
速度心面综合征（VCFS）是由22号染色体q11.2位点上超过40个基因的微缺失引起的，是精神分裂症和其他精神疾病发展的危险因素。COMT是位于缺失区的基因之一，被认为是精神疾病遗传易感性的主要候选基因。其功能多态性Val 108/158 Met已被证明影响前额叶功能和工作记忆，并与情绪失调有关。我们利用功能性磁共振成像（fMRI）事件相关的范例来评估COMT基因型和性别调节的神经激活的影响，引起观看情绪上的显着图像充满了愉快的，不愉快的，和中性的内容。由于雌激素下调COMT活性，导致女性COMT活性低于男性，因此我们假设等位基因与性别对神经激活的相互作用。参与者包括43名VCFS个体（瓦尔/男性=9，瓦尔/女性=17，Met/男性=9，Met/女性=8）。我们观察到性别对处理积极情绪的影响，女孩比男孩更能激活扣带回。我们进一步观察到一个显着的性别由等位基因的相互作用对神经功能的特定额叶在处理愉快的刺激，和特定的边缘区域在处理不愉快的刺激。我们的研究结果表明，在VCFS中，COMT Val 108/158 Met多态性的影响是由性别调节的情绪刺激的处理过程中，并可能有助于了解这种COMT多态性影响神经精神疾病的脆弱性的方式。
Velocardiofacial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases. Its functional polymorphism Val108/158Met has been shown to affect prefrontal function and working memory and has been associated with emotional dysregulation. We utilized a functional magnetic resonance imaging (fMRI) event-related paradigm to asses COMT genotype and gender-moderated effects on the neural activation that are elicited by viewing emotionally salient images charged with pleasant, unpleasant, and neutral content. Since estrogen down-regulates COMT activity resulting in lower COMT activity in women than men, we hypothesized an allele-by-gender interaction effect on neural activation. Participants included 43 VCFS individuals (Val/Male=9, Val/Female=17, Met/Male=9, Met/Female=8). We observed a gender effect on processing positive emotions, in that girls activated the cingulate gyrus more than boys. We further observed a significant gender-by-allele interaction effect on neural function specific to the frontal lobe during the processing of pleasant stimuli, and specific to limbic regions during the processing of unpleasant stimuli. Our results suggest that in VCFS, the effect of the COMT Val108/158Met polymorphism is moderated by gender during the processing of emotional stimuli and could contribute to the understanding of the way in which this COMT polymorphism affects vulnerability to neuropsychiatric disorders.
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DOI：
10.1111/j.1365-2788.2006.00859.x
发表时间：
2007-03-01
影响因子：
3.6
作者：
Antshel, K. M.;Stallone, K.;Kates, W. R.
通讯作者：
Kates, W. R.
DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
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通讯作者：
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影响因子：
3.7
作者：
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