The correlation of cytokines and sensory hypersensitivity in mild dry eye patients characterized by symptoms outweighing signs
The correlation of cytokines and sensory hypersensitivity in mild dry eye patients characterized by symptoms outweighing signs
复制标题
症状重于体征的轻度干眼患者细胞因子与感觉过敏的相关性
作者：
Bei Li;Ying Tian;Shuangyong Wang
目的 探讨症状大于体征（DESOS）的轻度干眼（MDE）患者泪液和结膜细胞因子与感觉超敏反应的相关性。方法受试者包括 39 名以 DESOS 为特征的 MDE 患者、18 名普通 MDE (CMDE) 患者和 15 名健康对照。接受DESOS的患者被随机分为两组； C-DESOS组仅给予人工泪液，G-DESOS组给予人工泪液和0.1%氟米龙滴眼液，每日3次。使用眼表面疾病指数（OSDI）和针对眼部修改的神经病理性疼痛症状清单（NPSI-E）问卷来评估症状。还采用了眼部检查和体内共聚焦显微镜（IVCM）。在第0、7和30天使用多重或RT-PCR测量泪液和结膜细胞因子。分析细胞因子表达与超敏状态之间的相关性。结果与CMDE组和对照组相比，DESOS组的症状评分和症状与体征的比率显着增加。与 CMDE 和对照组相比，DESOS 组泪液和结膜中的 IL-1β、IL-2、IL-6 和 TNF-α 有所增加，表明 DESOS 组与超敏状态高度相关。糖皮质激素治疗显着降低了 G-DESOS 组泪液和结膜中的细胞因子水平，随后改善了症状。结论 泪液和结膜细胞因子，包括 IL-1β、IL-2、IL-6 和 TNF-α，与 DESOS 组的感觉超敏状态相关，表明它们在症状大于体征的不一致中发挥重要作用。
Purpose To explore the correlation of tear and conjunctival cytokines and sensory hypersensitivity in mild dry eye (MDE) patients characterized by symptoms outweighing signs (DESOS). Methods The subjects comprised 39 patients with MDE characterized by DESOS, 18 patients with common MDE (CMDE), and 15 healthy controls. The patients with DESOS were randomly subdivided into two groups; the C-DESOS group received artificial tears only, and the G-DESOS group received artificial tears and 0.1% fluorometholone eye drops three times a day. Symptoms were assessed using the Ocular Surface Disease Index (OSDI) and the Neuropathic Pain Symptoms Inventory modified for Eye (NPSI-E) questionnaire. Ocular examinations and in vivo confocal microscopy (IVCM) were also employed. Tear and conjunctival cytokines were measured using Multiplex or RT–PCR on Days 0, 7, and 30. The correlation between the expression of cytokines and hypersensitivity status was analyzed. Results Compared with the CMDE and control groups, the DESOS groups showed a significant increase in symptom scores and in the ratio of symptoms versus signs. IL-1 β, IL-2, IL-6, and TNF-α in tears and conjunctiva increased in the DESOS groups compared to the CMDE and control groups, indicating a high correlation with hypersensitivity status in the DESOS groups. Glucocorticoid treatment significantly decreased the level of cytokines in tears and conjunctiva in the G-DESOS group and subsequently ameliorated the symptoms. Conclusions Tear and conjunctival cytokines, including IL-1 β, IL-2, IL-6, and TNF-α, were correlated with sensory hypersensitivity status in the DESOS groups, suggesting they play an important role in the discordance of symptoms outweighing signs.
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DOI：
10.1016/b978-0-7236-0794-6.50014-0
发表时间：
1985-06
影响因子：
0.8
作者：
R. Coakes;P. Sellors
通讯作者：
R. Coakes;P. Sellors
影响因子：
2.3
作者：
S. Sauer;P. Reeh
通讯作者：
S. Sauer;P. Reeh
影响因子：
4.4
作者：
Nichols, JJ;Sinnott, LT
通讯作者：
Sinnott, LT
影响因子：
4.5
作者：
Hamzaoui A;Maalmi H;Berraïes A;Abid H;Ammar J;Hamzaoui K
通讯作者：
Hamzaoui K
影响因子：
13.7
作者：
Vehof, Jelle;Smitt-Kamminga, Nicole Sillevis;Hammond, Christopher J.
通讯作者：
Hammond, Christopher J.