Perforin--a primary or auxiliary lytic mechanism?

Perforin--a primary or auxiliary lytic mechanism?
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穿孔素——主要或辅助裂解机制?

DOI:
10.1016/0167-5699(88)91277-7
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发表时间:
1988
期刊:
Immunology today
影响因子:
--
通讯作者:
W. Clark
W. Clark
中科院分区:
--
文献类型:
--
作者:
W. Clark

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含有成孔毒素的细胞毒性颗粒被认为是细胞介导的细胞毒性的主要机制。然而,根据最近的证据,威廉·克拉克在此提出,这可能是一种高度专业化的机制,仅在异常免疫应激的条件下起作用。虽然这种机制对于宿主的生存可能极其重要,但它可能无法解释细胞毒性细胞通常如何杀死其靶标。
Cytotoxic granules containing pore-forming toxins have been postulated to be the principal mechanism underlying cellmediated cytotoxicity. On the basis of recent evidence, however, William Clark suggests here that this may be a highly specialized mechanism operating only under conditions of unusual immunological stress. While this mechanism may be extremely important for host survival, it probably does not explain how cytotoxic cells normally kill their targets.
溶细胞 T 细胞颗粒:生化特性和功能特异性。
DOI: 10.1007/978-1-4684-8326-0_8
发表时间: 1985
影响因子: --
作者:
Podack,ER;Konigsberg,PJ;Acha-Orbea,H;Pircher,H;Hengartner,H
通讯作者: Hengartner,H