The adequate stimulus for mammalian linear vestibular evoked potentials (VsEPs).
The adequate stimulus for mammalian linear vestibular evoked potentials (VsEPs).
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DOI：
10.1016/j.heares.2011.05.005
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发表时间：
2011-10
期刊：
影响因子：
2.8
通讯作者：
Chabbert, Christian
中科院分区：
文献类型：
--
作者：
Jones, Timothy A.;Jones, Sherri M.;Vijayakumar, Sarath;Brugeaud, Aurore;Bothwell, Marcella;Chabbert, Christian
短潜伏期线性前庭感觉诱发电位（VsEPs）为客观、直接地评价哺乳动物和鸟类重力感受器功能提供了一种手段。这种功能措施的重要性说明了它在前庭功能和疾病的遗传基础的研究中的使用。头部运动是VsEP的刺激。在鸟类中，已经确定介导线性VsEP的神经元对头部运动期间线性加速度的变化率（即急动）而不是峰值加速度做出集体反应。负责触发哺乳动物VsEP的运动学元素尚未详细表征。在这里，我们测试的假设，加加速度是负责VsEP特征的头部运动的运动学组成部分。当峰值加速度保持不变，加加速度在~0.9 ~ 4.6g/ms范围内变化时，VsEP的幅值和潜伏期发生系统性变化，而当运动加加速度保持不变，峰值加速度在~0.9 ~ 5.5g范围内变化时，VsEP的反应相对稳定，而大鼠的反应相对稳定，峰值加速度在~0.44 ~ 2.75g范围内变化。因此，哺乳动物的VsEP取决于加加速度水平，而不是峰值加速度。我们的结论是，运动加加速度是足够的刺激哺乳动物的VsEP。这揭示了产生反应的神经元的行为。这些结果还为刺激水平的报告标准化提供了基础，这是确保许多实验室在文献中报告的反应特征可以有效地进行比较和解释的关键。
Short latency linear vestibular sensory evoked potentials (VsEPs) provide a means to objectively and directly assess the function of gravity receptors in mammals and birds. The importance of this functional measure is illustrated by its use in studies of the genetic basis of vestibular function and disease. Head motion is the stimulus for the VsEP. In the bird, it has been established that neurons mediating the linear VsEP respond collectively to the rate of change in linear acceleration during head movement (i.e. jerk) rather than peak acceleration. The kinematic element of motion responsible for triggering mammalian VsEPs has not been characterized in detail. Here we tested the hypothesis that jerk is the kinematic component of head motion responsible for VsEP characteristics. VsEP amplitudes and latencies changed systematically when peak acceleration level was held constant and jerk level was varied from ~0.9 to 4.6 g/ms. In contrast, responses remained relatively constant when kinematic jerk was held constant and peak acceleration was varied from ~0.9 to 5.5g in mice and ~0.44 to 2.75g in rats. Thus the mammalian VsEP depends on jerk levels and not peak acceleration. We conclude that kinematic jerk is the adequate stimulus for the mammalian VsEP. This sheds light on the behavior of neurons generating the response. The results also provide the basis for standardizing the reporting of stimulus levels, which is key to ensuring that response characteristics reported in the literature by many laboratories can be effectively compared and interpreted.
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DOI：
10.1007/s10162-005-0009-1
发表时间：
2005-12-01
影响因子：
2.4
作者：
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通讯作者：
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发表时间：
1992-05-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
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作者：
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通讯作者：
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DOI：
10.1007/s10162-008-0132-0
发表时间：
2008-12-01
影响因子：
2.4
作者：
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通讯作者：
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影响因子：
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作者：
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