Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy.
Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy.
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DOI：
10.1016/j.tvr.2021.200231
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发表时间：
2022-06
影响因子：
4.3
通讯作者：
Boon SS
中科院分区：
文献类型：
--
作者：
Li S;Luk HY;Xia C;Chen Z;Chan PKS;Boon SS
食管癌是癌症死亡的第六大原因，2020年影响了54.4万至60.4万人。患者预后差，生存率低，仅为15-25%。根据细胞类型，食管癌分为食管鳞状细胞癌（ESCC）和食管腺癌（EAC）。ESCC主要在发展中国家报告，而EAC在发达国家更为常见。除了存在外源性辅助因素，如吸烟、饮酒、肥胖、胃食管反流病（GERD）；感染致瘤病毒被怀疑是导致EC发展的主要因素之一。在EC样品中检测到不同比例的致瘤病毒，包括人乳头瘤病毒（HPV）、eb病毒（EBV）、巨细胞病毒（CMV）和单纯疱疹病毒（HSV）。尽管如此，它们在EC中的病因学作用仍有争议。在这篇综述中，我们收集了以往关于致癌病毒与EC之间关系的研究。在这些致癌病毒中，HPV似乎比其他病毒与EC有更强的联系。此外，我们还讨论了治疗EC患者的治疗方案的优缺点，包括免疫治疗、化疗和放化疗，以及它们的疗效。
Oesophageal carcinoma ranks the sixth leading cause of cancer death and affected 544,000 - 604,000 people in 2020. Patients often presented with a poor cancer prognosis with a low survival rate of 15–25%. Depending upon the cell type, oesophageal carcinoma is categorised into oesophageal squamous cell carcinoma (ESCC) and oesophageal adenocarcinoma (EAC). ESCC is predominantly reported in developing countries, while EAC is more common in developed countries. Aside from the presence of exogenous co-factors, such as cigarette smoking, alcohol consumption, obesity, gastroesophageal reflux disease (GERD); infection with oncogenic viruses is suspected to be one of the major factors contributing to EC development. Oncogenic viruses, including human papillomavirus (HPV), Epstein Barr virus (EBV), Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) have been detected in various proportions of EC samples. Nonetheless, their aetiological roles in EC remain debatable. In this review, we garnered previous studies that focus on the association between oncogenic viruses and EC. Among these oncogenic viruses, HPV appears to have a stronger association with EC than the others. In addition, we also discuss the pros and cons of the treatment regimens to treat EC patients, including immunotherapy, chemo- and chemoradiotherapy, and their efficacy.
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