REIA: A database for cancer A-to-I RNA editing with interactive analysis.
REIA: A database for cancer A-to-I RNA editing with interactive analysis.
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DOI：
10.7150/ijbs.69458
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发表时间：
2022
影响因子：
9.2
通讯作者：
Xiong Y
中科院分区：
文献类型：
--
作者：
Zhu H;Huang L;Liu S;Dai Z;Songyang Z;Weng Z;Xiong Y
Epitranscriptomic changes caused by adenosine-to-inosine (A-to-I) RNA editing contribute to the pathogenesis of human cancers; however, only a small fraction of the millions editing sites detected so far has clear functionality. To facilitate more in-depth studies on the editing, this paper offers REIA (http://bioinfo-sysu.com/reia), an interactive web server that analyses and visualizes the association between human cancers and A-to-I RNA editing sites (RESs). As a comprehensive database, REIA curates not only 8,447,588 RESs from 9,895 patients across 34 cancers, where 33 are from TCGA and 1 from GEO, but also 13 different types of multi-omic data for the cancers. As an interactive server, REIA provides various options for the user to specify the interested sites, to browse their annotation/editing level/profile in cancer, and to compare the difference in multi-omic features between editing and non-editing groups. From the editing profiles, REIA further detects 658 peptides that are supported by mass spectrum data but not yet covered in any prior works.
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