Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.
Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.
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DOI：
10.1016/j.atherosclerosis.2014.04.032
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发表时间：
2014-08
期刊：
影响因子：
5.3
通讯作者：
Koro, Carol
中科院分区：
文献类型：
--
作者：
Fitzpatrick, Annette L.;Irizarry, Michael C.;Cushman, Mary;Jenny, Nancy S.;Chi, Gloria C.;Koro, Carol
To evaluate associations between Lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity with risk of dementia and its subtypes. Analysis were completed on 3,320 participants of the Cardiovascular Health Study (CHS), a population-based longitudinal study of community-dwelling adults age ≥ 65 years followed for an average of 5.4 years. Baseline serum Lp-PLA2 mass was measured using a sandwich enzyme immunoassay and Lp-PLA2 activity utilized a tritiated-platelet activating factor activity assay. Cox proportional hazards regression assessed the relative risk of incident dementia with higher baseline Lp-PLA2 adjusting for demographics, cardiovascular disease (CVD) and risk factors, inflammation markers and apolipoprotein E (APOE) genotype. Each standard deviation higher Lp-PLA2 mass and activity were related to increased risk of dementia (fully adjusted HR:1.11 per SD, 95% CI:1.00-1.24 for mass; HR:1.12 per SD, 95% CI:1.00-1.26 for activity). Persons in the highest quartile of Lp-PLA2 mass were 50% more likely to develop dementia than those in the lowest quartile in adjusted models (HR: 1.49; 95% CI: 1.08-2.06). Among dementia subtypes, the risk of AD was increased two-fold in the highest compared to lowest quartile of Lp-PLA2 mass (adjusted HR:1.98, 95% CI:1.22-3.21). Results were attenuated in models of mixed dementia and VaD. Lp-PLA2 activity also doubled the risk of mixed dementia in the highest compared to lowest quartile (HR:2.21, 95% CI:1.12-4.373). These data support Lp-PLA2 as a risk factor for dementia independent of CVD and its risk factors. Further study is required to clarify the role of Lp-PLA2-related mechanisms in dementia subtypes.
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影响因子：
8.3
作者：
OLEARY, DH;POLAK, JF;MANOLIO, TA
通讯作者：
MANOLIO, TA
影响因子：
158.5
作者：
Packard, CJ;O'Reilly, DSJ;Lowe, GDO
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Lowe, GDO
DOI：
10.1111/j.1532-5415.2008.01667.x
发表时间：
2008-05-01
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作者：
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作者：
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通讯作者：
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