IDH-1R132H mutation status in diffuse glioma patients: implications for classification.
IDH-1R132H mutation status in diffuse glioma patients: implications for classification.
复制标题
DOI：
10.18632/oncotarget.8918
复制
发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Yan CX
中科院分区：
文献类型：
--
作者：
Wang PF;Liu N;Song HW;Yao K;Jiang T;Li SW;Yan CX
WHO 2007对成人弥漫性胶质瘤的分级是公认的。然而，IDH突变使得根据WHO 2007版对胶质瘤的分类存在争议。在此，我们对670例具有不同WHO 2007分级的弥漫性胶质瘤成人患者的IDH-1 R132 H突变状态进行了研究。从病历中获得患者特征、临床数据和病历。携带IDH-1 R132 H突变的患者比没有突变的患者更年轻，临床结局更好。在根据IDH-1 R132 H状态对患者进行分组后，消除了不同WHO 2007分级的星形细胞瘤患者之间的年龄差异。IDH-1 R132 H mut在Ki-67和MGMT蛋白水平较低和突变型p53水平较高的患者中更常见。Ki-67也与WHO 2007分级密切相关，独立于IDH-1 R132 H mut状态。此外，Ki-67<30的患者比Ki-67≥30的患者存活时间更长，无论IDH-1 R132 H mut状态如何。具有较低MGMT蛋白水平的IDH-1 R132 H mut组患者的临床结局也优于其他组。我们的研究结果表明，为了更好地治疗胶质瘤，IDH突变状态应包括在确定WHO 2007分级胶质瘤患者。
WHO2007 grading of diffuse gliomas in adults is well-established. However, IDH mutations make classification of gliomas according to the WHO2007 edition controversial. Here, we characterized IDH-1R132H mut status in a cohort of 670 adult patients with different WHO2007 grades of diffuse glioma. Patient characteristics, clinical data and prognoses were obtained from medical records. Patients with IDH-1R132H mut were younger and had better clinical outcomes than those without mutations. Differences in age among patients with astrocytomas of different WHO2007 grades were eliminated after patients were grouped based on IDH-1R132H status. IDH-1R132H mut was present more often in patients with lower Ki-67 and MGMT protein levels and higher mutant p53 levels. Ki-67 was also strongly associated with WHO2007 grade independently of IDH-1R132H mut status. Moreover, patients with Ki-67<30 survived longer than those with Ki-67≥30, regardless of IDH-1R132H mut status. Patients in the IDH-1R132H mut group with lower MGMT protein levels also had better clinical outcomes than those in other groups. Our results indicate that to better treat gliomas, IDH mutation status should be included when determining WHO2007 grade in glioma patients.
登录
查看更多内容
影响因子：
12.7
作者：
Hartmann, Christian;Meyer, Jochen;von Deimling, Andreas
通讯作者：
von Deimling, Andreas
DOI：
10.3322/caac.20069
发表时间：
2010-05
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Van Meir EG;Hadjipanayis CG;Norden AD;Shu HK;Wen PY;Olson JJ
通讯作者：
Olson JJ
影响因子：
--
作者：
Wang XW;Ciccarino P;Rossetto M;Boisselier B;Marie Y;Desestret V;Gleize V;Mokhtari K;Sanson M;Labussière M
通讯作者：
Labussière M
影响因子：
15.9
作者：
Dolecek, Therese A.;Propp, Jennifer M.;Kruchko, Carol
通讯作者：
Kruchko, Carol
影响因子：
45.3
作者：
Sanson, Marc;Marie, Yannick;Delattre, Jean-Yves
通讯作者：
Delattre, Jean-Yves