On the ultrastructural localization of noradrenaline in the central nervous system of the rat
On the ultrastructural localization of noradrenaline in the central nervous system of the rat
复制标题
去甲肾上腺素在大鼠中枢神经系统的超微结构定位
DOI：
10.1007/bf00335247
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
T. Hökfelt
中科院分区：
文献类型：
--
作者：
T. Hökfelt
本文用高锰酸钾作固定剂，对大白鼠蓝斑区进行了电镜观察，发现蓝斑区有一种特殊类型的囊泡，其中含有许多直径约500 μ m的颗粒囊泡，即小颗粒囊泡。在同一个终扣中也发现了一些大颗粒囊泡和无颗粒囊泡，但在大多数终扣中没有发现小颗粒囊泡，而以无颗粒囊泡为主。在蓝斑的胞体中也发现了小颗粒囊泡，而在以前用戊二醛和四氧化锇作固定剂的研究中没有发现这样的小颗粒囊泡。目前的结果被解释为证据的观点，即按照以前的研究结果，在我们的实验室的小颗粒囊泡的存储网站去甲肾上腺素在中枢神经系统。
SummaryThe locus coeruleus area of rat, a brain area rich in both noradrenaline nerve cell bodies and nerve terminals, has been investigated with electron microscope using potassium permanganate as a fixative.In this area a special type of bouton was found containing many granular vesicles with a diameter of about 500 Å, so called small granular vesicles. In the same bouton also some large granular vesicles and agranular vesicles were found. In the majority of boutons, however, no small granular vesicles were found but predominantly agranular vesicles. Also in the cell bodies of the locus coeruleus small granular vesicles were found. In previous studies using glutaraldehyde and osmium tetroxide as fixatives no such small granular vesicles were seen. The present results are interpreted to give evidence for the view, that in accordance with previous findings in our laboratory the small granular vesicles are storage sites for noradrenaline in the central nervous system.
影响因子：
2.4
作者：
Byr R. E. Coupland
通讯作者：
Byr R. E. Coupland