Effect of four rounds of annual school-wide mass praziquantel treatment for schistosoma mansoni control on schistosome-specific immune responses.
Effect of four rounds of annual school-wide mass praziquantel treatment for schistosoma mansoni control on schistosome-specific immune responses.
复制标题
四轮全年学校质量质量治疗对曼氏菌的血吸虫控制对血吸虫特异性免疫反应的影响。
DOI：
10.1111/pim.12530
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发表时间：
2018-06
影响因子：
2.2
通讯作者：
Colley DG
中科院分区：
文献类型：
--
作者：
Ndombi EM;Abudho B;Kittur N;Carter JM;Korir H;Riner DK;Ochanda H;Lee YM;Secor WE;Karanja DM;Colley DG
This study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross‐sectional study design, 210 schistosome egg‐positive children were recruited at baseline from schools in western Kenya (baseline group). Another 251 children of the same age range were recruited from the same schools and diagnosed with schistosome infection by microscopy (post‐MDA group). In‐vitro schistosome‐specific cytokines and plasma antibody levels were measured by ELISA and compared between the 2 groups of children. Schistosome soluble egg antigen (SEA) and soluble worm antigen preparation (SWAP) stimulated higher IL‐5 production by egg‐negative children in the post‐MDA group compared to the baseline group. Similarly, anti‐SEA IgE levels were higher in egg‐negative children in the post‐MDA group compared to the baseline group. Anti‐SEA and anti‐SWAP IgG4 levels were lower in egg‐negative children in the post‐MDA group compared to baseline. This resulted in higher anti‐SEA IgE/IgG4 ratios for children in the post‐MDA group compared to baseline. These post‐MDA immunological changes are compatible with the current paradigm that treatment shifts immune responses to higher antischistosome IgE:IgG4 ratios in parallel with a potential increase in resistance to reinfection.
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DOI：
10.4269/ajtmh.17-0908
发表时间：
2018-05
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Abudho BO;Ndombi EM;Guya B;Carter JM;Riner DK;Kittur N;Karanja DMS;Secor WE;Colley DG
通讯作者：
Colley DG
影响因子：
2.8
作者：
DUNNE, DW;BUTTERWORTH, AE;STURROCK, RF
通讯作者：
STURROCK, RF
DOI：
10.4269/ajtmh.1986.35.793
发表时间：
1986-07-01
影响因子：
3.3
作者：
COLLEY, DG;GARCIA, AA;GAZZINELLI, G
通讯作者：
GAZZINELLI, G
影响因子：
6.4
作者：
Grogan, JL;Kremsner, PG;Yazdanbakhsh, M
通讯作者：
Yazdanbakhsh, M
影响因子：
3.8
作者：
Mbanefo EC;Huy NT;Wadagni AA;Eneanya CI;Nwaorgu O;Hirayama K
通讯作者：
Hirayama K