Dynamics and function of the tear film in relation to the blink cycle.
Dynamics and function of the tear film in relation to the blink cycle.
复制标题
DOI：
10.1016/j.preteyeres.2014.11.001
复制
发表时间：
2015-03
影响因子：
17.8
通讯作者：
Gewecke, N. R.
中科院分区：
文献类型：
--
作者：
Braun, R. J.;King-Smith, P. E.;Begley, C. G.;Li, Longfei;Gewecke, N. R.
最近在泪膜厚度和变薄的定量测量、其数学建模以及将这些与感官知觉联系起来方面取得了长足的进步。本文总结了这些领域的最新进展，并报告了新的结果。完整的眨眼周期被用作一个框架，试图统一目前可用的结果。泪膜动力学的理解是通过结合来自不同成像方法的信息来帮助的，这些成像方法包括荧光、后向照明和为研究眨眼周期期间的泪膜而开发的新的高速频闪成像系统。在眨眼的下行程期间，脂质被压缩为刚好在上眼睑下的厚层，其通常在上行程开始时作为窄的厚脂质带释放。由于泪膜在角膜表面上的运动，泪膜/空气界面的“波纹”，有点像水在岩石河床上的浅流中的流动，在眼睑运动期间观察到，并在这里进行理论处理。新的数学预测的泪膜渗透压在暴露的眼表和眼泪破裂，后者是密切相关的新的体内观察。模型包括蒸发、通过角膜和结膜的渗透流、荧光淬灭、含水泪液的切向流以及泪液溶质和荧光素的扩散的影响。这些和其他实验和理论的结合增加了我们对泪膜的流体动力学及其对眼表的潜在影响的理解。
Great strides have recently been made in quantitative measurements of tear film thickness and thinning, mathematical modeling thereof and linking these to sensory perception. This paper summarizes recent progress in these areas and reports on new results. The complete blink cycle is used as a framework that attempts to unify the results that are currently available. Understanding of tear film dynamics is aided by combining information from different imaging methods, including fluorescence, retroillumination and a new high-speed stroboscopic imaging system developed for studying the tear film during the blink cycle. During the downstroke of the blink, lipid is compressed as a thick layer just under the upper lid which is often released as a narrow thick band of lipid at the beginning of the upstroke. “Rippling” of the tear film/air interface due to motion of the tear film over the corneal surface, somewhat like the flow of water in a shallow stream over a rocky streambed, was observed during lid motion and treated theoretically here. New mathematical predictions of tear film osmolarity over the exposed ocular surface and in tear breakup are presented; the latter is closely linked to new in vivo observations. Models include the effects of evaporation, osmotic flow through the cornea and conjunctiva, quenching of fluorescence, tangential flow of aqueous tears and diffusion of tear solutes and fluorescein. These and other combinations of experiment and theory increase our understanding of the fluid dynamics of the tear film and its potential impact on the ocular surface.
登录
查看更多内容
影响因子：
3.3
作者：
Casalini, Tommaso;Salvalaglio, Matteo;Cavallotti, Carlo
通讯作者：
Cavallotti, Carlo
影响因子：
4.4
作者：
Chen, Zhuo;Tong, Louis;Pflugfelder, Stephen C.
通讯作者：
Pflugfelder, Stephen C.
影响因子：
--
作者：
ARCHER, RJ;LAMER, VK
通讯作者：
LAMER, VK
影响因子：
1.4
作者：
Craig, JP;Tomlinson, A
通讯作者：
Tomlinson, A
影响因子：
6.4
作者：
Cruz, Antonio A. V.;Garcia, Denny M.;Cechetti, Sheila P.
通讯作者：
Cechetti, Sheila P.