Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.
Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.
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DOI：
10.1007/s10552-015-0526-3
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发表时间：
2015-03
影响因子：
2.3
通讯作者：
Rutter, Carolyn M.
中科院分区：
文献类型：
--
作者：
Passarelli, Michael N.;Newcomb, Polly A.;Makar, Karen W.;Burnett-Hartman, Andrea N.;Potter, John D.;Upton, Melissa P.;Zhu, Lee-Ching;Rosenfeld, Michael E.;Schwartz, Stephen M.;Rutter, Carolyn M.
将胆固醇水平与结直肠肿瘤发展联系起来的研究并不一致，孟德尔随机化被认为是帮助避免混杂和反向因果关系问题的一种方法。我们对在 Group Health (1998-2007) 接受结肠镜检查的个体进行了基因分型，其中包括全球脂质遗传学联盟 (Global Lipids Genetics Consortium) 鉴定的 102 个单核苷酸多态性 (SNP) 中的 96 个。参与者包括 139 例晚期腺瘤病例、518 例非晚期腺瘤病例、380 例非腺瘤性息肉病例和 754 例无息肉对照。所有患者都至少有一项来自 Group Health 维护的电子记录的结肠镜检查前血脂测量结果。晚期腺瘤病例比对照组更有可能具有更高的结肠镜检查前最高低密度脂蛋白 (LDL)、甘油三酯 (TG) 和总胆固醇 (TC)（比值比，OR，每 20 mg/dL LDL 增加：1.16，95% 置信区间，CI，1.03–1.30；每 40 mg/dL TG 增加：1.09， 1.03–1.16；每增加 20 mg/dL TC：1.09、1.02–1.18）。对于这些性状，使用加权等位基因评分的基因型息肉 OR 不具有统计学显着性（每增加 20 mg/dL LDL 增加的 OR 值：1.17、0.78–1.75；40 mg/dL TG 增加：1.12、0.91–1.38；20 mg/dL TC 增加：0.99， 0.71–1.38）。胆固醇水平可能与晚期腺瘤有关，但需要进行更大规模的研究来确定这种关联是否可归因于遗传学。
Studies linking cholesterol levels to the development of colorectal neoplasia are inconsistent, and Mendelian randomization has been suggested as a way to help avoid problems with confounding and reverse causation. We genotyped individuals who received a colonoscopy at Group Health (1998–2007) for 96 of 102 single-nucleotide polymorphisms (SNPs) identified by the Global Lipids Genetics Consortium. Participants included 139 advanced adenoma cases, 518 non-advanced adenoma cases, 380 non-adenomatous polyp cases, and 754 polyp-free controls. All had at least one available pre-colonoscopy lipid measurement from electronic records maintained by Group Health. Advanced adenoma cases were more likely than controls to have higher pre-colonoscopy zenith low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol (TC) (odds ratio, OR, per 20 mg/dL LDL increase: 1.16, 95% confidence interval, CI, 1.03–1.30; per 40 mg/dL TG increase: 1.09, 1.03–1.16; and per 20 mg/dL TC increase: 1.09, 1.02–1.18). For these traits, genotype-polyp ORs using weighted allele scores were not statistically significant (OR per increase in score scaled to a 20 mg/dL LDL increase: 1.17, 0.78–1.75; a 40 mg/dL TG increase: 1.12, 0.91–1.38; a 20 mg/dL TC increase: 0.99, 0.71–1.38). Cholesterol levels may be associated with advanced adenomas, but larger studies are warranted to determine whether this association can be attributed to genetics.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1016/s1052-5157(03)00053-9
发表时间：
2002-01-01
影响因子：
--
作者：
Winawer, Sidney J;Zauber, Ann G
通讯作者：
Zauber, Ann G
DOI：
10.1097/ede.0000000000000081
发表时间：
2014-05
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
VanderWeele TJ;Tchetgen Tchetgen EJ;Cornelis M;Kraft P
通讯作者：
Kraft P
影响因子：
7.7
作者：
Brion, Marie-Jo A.;Shakhbazov, Konstantin;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
影响因子：
3.8
作者：
Barnholtz-Sloan, JS;Chakraborty, R;Schwartz, AG
通讯作者：
Schwartz, AG