Prenatal Exposure to a Climate-Related Disaster Results in Changes of the Placental Transcriptome and Infant Temperament.
Prenatal Exposure to a Climate-Related Disaster Results in Changes of the Placental Transcriptome and Infant Temperament.
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DOI：
10.3389/fgene.2022.887619
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发表时间：
2022
影响因子：
3.7
通讯作者：
Liu, Jia
中科院分区：
文献类型：
--
作者：
Buthmann, Jessica;Huang, Dennis;Casaccia, Patrizia;O'Neill, Sarah;Nomura, Yoko;Liu, Jia
母亲在怀孕期间的压力对后代的心理健康产生长期影响。然而，产前暴露对后代精神状态的长期影响仅部分了解。胎盘在连接母体与胎儿方面起着至关重要的作用，因此是母体暴露与胎儿发育之间的重要界面。在这里，我们分析了在2012年袭击纽约市的飓风（超级风暴桑迪）期间怀孕的妇女的胎盘转录组。对这些后代进行纵向随访，并在最初6-12个月的年龄内评估其气质。这些数据确定了超级风暴桑迪压力因素评分和婴儿气质之间的显着相关性。此外，胎盘转录组的分析确定了与炎症，细胞外基质的完整性和感官知觉的标本中的功能途径的丰富，从那些婴儿在生命的第一年期间的“慢热身”气质。总之，这些发现提供了初步证据，表明母亲暴露于与气候相关的灾害导致胎盘转录组改变，这可能与儿童的长期情绪和行为后果有关。
Maternal stress during pregnancy exerts long-term effects on the mental well-being of the offspring. However, the long-term effect of prenatal exposure on the offspring’s mental status is only partially understood. The placenta plays a vital role in connecting the maternal side to the fetus, thereby serving as an important interface between maternal exposure and fetal development. Here, we profiled the placental transcriptome of women who were pregnant during a hurricane (Superstorm Sandy), which struck New York City in 2012. The offspring were followed longitudinally and their temperament was assessed during the first 6–12 months of age. The data identified a significant correlation between a Superstorm Sandy stress factor score and infant temperament. Further, analysis of the placental transcriptomes identified an enrichment of functional pathways related to inflammation, extracellular matrix integrity and sensory perception in the specimen from those infants with “Slow-to-Warm-up” temperament during the first year of life. Together, these findings provide initial evidence that maternal exposure to climate-related disasters results in altered placental transcriptome, which may be related to long-term emotional and behavioral consequences in children.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
2.9
作者：
Case-Smith, J;Butcher, L;Reed, D
通讯作者：
Reed, D
影响因子：
11
作者：
Nomura Y;Rompala G;Pritchett L;Aushev V;Chen J;Hurd YL
通讯作者：
Hurd YL
影响因子：
4.8
作者：
Bronson, Stefanie L.;Bale, Tracy L.
通讯作者：
Bale, Tracy L.
影响因子：
5.8
作者：
Lachmann, Alexander;Xu, Huilei;Ma'ayan, Avi
通讯作者：
Ma'ayan, Avi