Ophthalmologic stem cell transplantation therapies.
Ophthalmologic stem cell transplantation therapies.
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DOI：
10.2217/rme.12.77
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发表时间：
2012-11
影响因子：
2.7
通讯作者：
Stern JH
中科院分区：
文献类型：
--
作者：
Blenkinsop TA;Corneo B;Temple S;Stern JH
视力丧失是一个重大的社会问题，仅在美国就有超过2000万18岁以上的人受到影响。根据消费者研究协会最近的一项调查，视力丧失比过早死亡或心血管疾病更令人担忧。据估计，2010年，最普遍的眼病-年龄相关性黄斑变性-的年度直接医疗费用为2，550亿美元，由于生产力损失以及家庭和社区护理视力残疾的负担，造成了880亿美元的额外经济影响。随着人类干细胞研究的蓬勃发展，再生治疗正在开发，可以帮助减轻这种负担。动物研究的积极结果表明，基于干细胞的移植可以保护并潜在地改善视力。这导致了对几种眼科疾病的新的临床试验，并取得了令人鼓舞的结果。在接下来的几年里，更多的试验和长期结果预计将进一步开发眼部再生疗法，并有可能彻底改变我们治疗眼科疾病和损伤的方法。
Vision loss is a major social issue, with more than 20 million people over the age of 18 years affected in the USA alone. Loss of vision is feared more than premature death or cardiovascular disease, according to a recent Society for Consumer Research group survey. The annual direct cost of medical care for the most prevalent eye disease, age-related macular degeneration, was estimated at US$255 billion in 2010 with an additional economic impact of US$88 billion due to lost productivity and the burden of family and community care for visual disability. With the blossoming of human stem cell research, regenerative treatments are now being developed that can help reduce this burden. Positive results from animal studies demonstrate that stem cell-based transplants can preserve and potentially improve vision. This has led to new clinical trials for several eye diseases that are yielding encouraging results. In the next few years, additional trials and longer-term results are anticipated to further develop ocular regenerative therapies, with the potential to revolutionize our approach to ophthalmic disease and damage.
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影响因子：
3.7
作者：
Jin ZB;Okamoto S;Osakada F;Homma K;Assawachananont J;Hirami Y;Iwata T;Takahashi M
通讯作者：
Takahashi M
DOI：
10.1089/clo.2006.8.189
发表时间：
2006-09-01
期刊：
CLONING AND STEM CELLS
影响因子：
--
作者：
Lund, Raymond D.;Wang, Shaomei;Lanza, Robert
通讯作者：
Lanza, Robert
DOI：
10.1007/s00417-006-0382-7
发表时间：
2007-03-01
影响因子：
2.7
作者：
Arnhold, S.;Absenger, Y.;Schraermeyer, U.
通讯作者：
Schraermeyer, U.
影响因子：
4
作者：
Chaudhry, G. Rasul;Fecek, Christopher;Trese, Michael T.
通讯作者：
Trese, Michael T.
影响因子：
5.3
作者：
Kwan, ASL;Wang, S;Lund, RD
通讯作者：
Lund, RD