Modulation of the Association between the PEPD Variant and the Risk of Type 2 Diabetes by n-3 Fatty Acids in Chinese Hans
Modulation of the Association between the PEPD Variant and the Risk of Type 2 Diabetes by n-3 Fatty Acids in Chinese Hans
复制标题
中国汉族人中 n-3 脂肪酸对 PEPD 变异与 2 型糖尿病风险之间关系的调节
DOI：
10.1159/000381348
复制
发表时间：
2015-06
影响因子：
--
通讯作者：
Li, Duo
中科院分区：
文献类型：
--
作者：
Xie, Hua;Xu, Danfeng;Sun, Jianqin;Li, Duo
背景/目标：2 型糖尿病 (T2D) 受到遗传因素和饮食因素之间相互作用的调节。本研究旨在探讨中国汉族人群中全基因组关联研究 (GWAS) 确定的遗传变异与 T2D 风险之间的关联是否受到 n-3 脂肪酸的调节。方法：招募了 622 名 T2D 患者和 293 名健康对照者。通过标准方法测量红细胞磷脂脂肪酸。对 GWAS 鉴定的 9 个 T2D 相关单核苷酸多态性 (SNP) 进行了基因分型。这些 SNP 均在亚洲人群的 GWAS 中被发现，具有较高的次要等位基因频率 (>0.2)。结果：在9个SNP中，只有PEPD（肽酶D）处的rs3786897显示出与n-3脂肪酸的显着相互作用（Bonferroni校正后的p相互作用= 0.027）。当 n-3 脂肪酸低于人群中位数时，rs3786897 A 等位基因与较高的 T2D 风险相关[GA+AA 与 GG：比值比 (OR) = 2.16，95% 置信区间 (CI) 1.32-3.55]，但未观察到显着关联（GA+AA 与 GG：OR = 0.63，95% CI 0.35-1.12）当 n-3 脂肪酸高于中位数时。结论：PEPD 遗传变异与 T2D 风险之间的关联受 n-3 脂肪酸调节。较高的 n-3 脂肪酸可以消除 PEPD 风险等位基因对 T2D 的不利影响。
Background/Aims: Type 2 diabetes (T2D) is modulated by the interactions between genetic and dietary factors. This study sought to examine whether the associations of genome-wide association study (GWAS)-identified genetic variants with T2D risk were modulated by n-3 fatty acids in Chinese Hans. Methods: Six hundred and twenty-two T2D patients and 293 healthy controls were recruited. Erythrocyte phospholipid fatty acids were measured by standard methods. Nine GWAS-identified T2D-related single-nucleotide polymorphisms (SNPs) were genotyped. These SNPs were all identified in GWAS of Asian populations with a high minor allele frequency (>0.2). Results: Among the 9 SNPs, only rs3786897 at PEPD (peptidase D) showed a significant interaction with n-3 fatty acids (pinteraction after Bonferroni correction = 0.027). The rs3786897 A allele was associated with a higher risk of T2D [GA+AA vs. GG: odds ratio (OR) = 2.16, 95% confidence interval (CI) 1.32-3.55] when n-3 fatty acids were lower than the population median, but no significant association (GA+AA vs. GG: OR = 0.63, 95% CI 0.35-1.12) was observed when n-3 fatty acids were higher than the median. Conclusions: The association between the PEPD genetic variant and the risk of T2D was modulated by n-3 fatty acids. Higher n-3 fatty acids may abolish the adverse effect of the risk allele at PEPD for T2D.
登录
查看更多内容
影响因子：
16.2
作者：
Nettleton JA;McKeown NM;Kanoni S;Lemaitre RN;Hivert MF;Ngwa J;van Rooij FJ;Sonestedt E;Wojczynski MK;Ye Z;Tanaka T;Garcia M;Anderson JS;Follis JL;Djousse L;Mukamal K;Papoutsakis C;Mozaffarian D;Zillikens MC;Bandinelli S;Bennett AJ;Borecki IB;Feitosa MF;Ferrucci L;Forouhi NG;Groves CJ;Hallmans G;Harris T;Hofman A;Houston DK;Hu FB;Johansson I;Kritchevsky SB;Langenberg C;Launer L;Liu Y;Loos RJ;Nalls M;Orho-Melander M;Renstrom F;Rice K;Riserus U;Rolandsson O;Rotter JI;Saylor G;Sijbrands EJ;Sjogren P;Smith A;Steingrímsdóttir L;Uitterlinden AG;Wareham NJ;Prokopenko I;Pankow JS;van Duijn CM;Florez JC;Witteman JC;MAGIC Investigators;Dupuis J;Dedoussis GV;Ordovas JM;Ingelsson E;Cupples L;Siscovick DS;Franks PW;Meigs JB
通讯作者：
Meigs JB
全基因组关联研究确定 GRK5 和 RASGRP1 为中国汉族 2 型糖尿病基因座
影响因子：
7.7
作者：
Li H;Gan W;Lu L;Dong X;Han X;Hu C;Yang Z;Sun L;Bao W;Li P;He M;Sun L;Wang Y;Zhu J;Ning Q;Tang Y;Zhang R;Wen J;Wang D;Zhu X;Guo K;Zuo X;Guo X;Yang H;Zhou X;DIAGRAM Consortium;AGEN-T2D Consortium;Zhang X;Qi L;Loos RJ;Hu FB;Wu T;Liu Y;Liu L;Yang Z;Hu R;Jia W;Ji L;Li Y;Lin X
通讯作者：
Lin X
全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
DOI：
10.1152/ajpendo.00695.2006
发表时间：
2007-07-01
影响因子：
5.1
作者：
Liao, Wei;Nguyen, M. T. Audrey;Olefsky, Jerrold M.
通讯作者：
Olefsky, Jerrold M.
影响因子：
7.7
作者：
Takeuchi F;Serizawa M;Yamamoto K;Fujisawa T;Nakashima E;Ohnaka K;Ikegami H;Sugiyama T;Katsuya T;Miyagishi M;Nakashima N;Nawata H;Nakamura J;Kono S;Takayanagi R;Kato N
通讯作者：
Kato N