MAP'ing CNS development and cognition: an ERKsome process.

MAP'ing CNS development and cognition: an ERKsome process.
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DOI:
10.1016/j.neuron.2009.01.001
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发表时间:
2009-01-29
期刊:
影响因子:
16.2
通讯作者:
Landreth, Gary E.
Landreth, Gary E.
中科院分区:
医学1区
文献类型:
--
作者:
Samuels, Ivy S.;Saitta, Sulagna C.;Landreth, Gary E.

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The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.
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