Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention.
Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention.
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DOI：
10.3390/biom11101441
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发表时间：
2021-09-30
期刊：
影响因子：
5.5
通讯作者：
Rucker RB
中科院分区：
文献类型：
--
作者：
Jonscher KR;Chowanadisai W;Rucker RB
吡咯并喹啉醌（PQQ）与生物学过程如生殖、生长和衰老有关。此外，PQQ减弱临床相关的功能障碍（例如，与局部缺血、炎症和脂毒性相关的那些）。PQQ是目前不被接受为维生素或条件性维生素的生物因子中的新生物因子。例如，饮食中缺乏PQQ会产生类似维生素相关缺乏的反应，PQQ以剂量依赖性方式补充后恢复。此外，潜在的健康益处，如改善代谢灵活性以及免疫和神经保护，与PQQ补充有关。在这里，我们解决PQQ的作用作为酶的辅助因子或辅助因子，并强调PQQ的行动的机制。我们回顾了大规模和有针对性的数据集，表明新生儿或围产期PQQ缺乏症会降低线粒体含量和肾脏相关基因表达。综述的数据表明，PQQ的乳酸和其他脱氢酶的调制增强NAD+依赖性沉默调节蛋白的活性，沿着沉默调节蛋白的目标，如PGC-1α，NRF-1，NRF-2和TFAM，从而介导线粒体功能。综上所述，目前的观察表明，维生素样PQQ作为一种有效的治疗性营养药物具有很强的潜力。
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and lipotoxicity). PQQ is novel among biofactors that are not currently accepted as vitamins or conditional vitamins. For example, the absence of PQQ in diets produces a response like a vitamin-related deficiency with recovery upon PQQ repletion in a dose-dependent manner. Moreover, potential health benefits, such as improved metabolic flexibility and immuno-and neuroprotection, are associated with PQQ supplementation. Here, we address PQQ’s role as an enzymatic cofactor or accessory factor and highlight mechanisms underlying PQQ’s actions. We review both large scale and targeted datasets demonstrating that a neonatal or perinatal PQQ deficiency reduces mitochondria content and mitochondrial-related gene expression. Data are reviewed that suggest PQQ’s modulation of lactate acid and perhaps other dehydrogenases enhance NAD+-dependent sirtuin activity, along with the sirtuin targets, such as PGC-1α, NRF-1, NRF-2 and TFAM; thus, mediating mitochondrial functions. Taken together, current observations suggest vitamin-like PQQ has strong potential as a potent therapeutic nutraceutical.
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影响因子：
3.7
作者：
Bauerly K;Harris C;Chowanadisai W;Graham J;Havel PJ;Tchaparian E;Satre M;Karliner JS;Rucker RB
通讯作者：
Rucker RB
影响因子：
15
作者：
Chan, Sunney I.;Chuankhayan, Phimonphan;Chen, Chun-Jung
通讯作者：
Chen, Chun-Jung
DOI：
10.3390/molecules190812727
发表时间：
2014-08-20
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Choi BH;Kang KS;Kwak MK
通讯作者：
Kwak MK
DOI：
10.1016/j.jstrokecerebrovasdis.2021.105702
发表时间：
2021-09
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Choi B;Crouzet C;Lau WL;Cribbs DH;Fisher MJ
通讯作者：
Fisher MJ
影响因子：
9.3
作者：
Boddy SL;Giovannelli I;Sassani M;Cooper-Knock J;Snyder MP;Segal E;Elinav E;Barker LA;Shaw PJ;McDermott CJ
通讯作者：
McDermott CJ