Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches.
Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches.
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DOI：
10.3389/fendo.2021.785050
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wu ZB
中科院分区：
文献类型：
--
作者：
Han C;Lin S;Lu X;Xue L;Wu ZB
巨噬细胞是最常见的浸润性免疫细胞之一，是肿瘤微环境的重要组成部分。巨噬细胞及其产生的可溶性细胞因子和趋化因子在实体瘤的发生、发展、侵袭和转移中起着重要作用。尽管在其他实体瘤中有大量研究，但巨噬细胞在垂体腺瘤中的作用知之甚少。近年来，关于垂体腺瘤浸润巨噬细胞的研究不断涌现，包括垂体腺瘤的免疫组化和免疫表型分析，以及巨噬细胞与肿瘤细胞在体内和体外串扰机制的进一步研究。这些研究为巨噬细胞极化及其在垂体腺瘤发生、发展和侵袭中的作用提供了新的认识。本文就垂体腺瘤浸润性巨噬细胞的研究进展及巨噬细胞靶向治疗垂体腺瘤的前景作一综述。
Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma.
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影响因子：
4.1
作者：
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通讯作者：
Wu, Zhe Bao
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通讯作者：
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30.5
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影响因子：
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作者：
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通讯作者：
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