Optimized Inner-Volume 3D TSE for High-Resolution Vessel Wall Imaging of Intracranial Perforating Arteries at 7T.
Optimized Inner-Volume 3D TSE for High-Resolution Vessel Wall Imaging of Intracranial Perforating Arteries at 7T.
复制标题
优化的内容积3D TSE用于7T下颅内穿通动脉的高分辨率血管壁成像。
DOI：
10.3389/fnins.2021.620172
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发表时间：
2021
影响因子：
4.3
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Kong Q;Wu Y;Weng D;An J;Zhuo Y;Zhang Z
微血管损伤可导致神经系统疾病，如中风和血管性痴呆。穿支动脉的管腔和血管壁的成像由于其小口径尺寸而需要极高的分辨率。目前的影像学技术难以观察穿支动脉壁。在这项研究中，我们开发了一个三维内体积（IV）TSE（SPACE）序列与优化的二维空间选择性激发（SSE）RF脉冲。通过迭代RF脉冲设计、轨迹优化和Carr-Purcell-Meiboom-Gill（CPMG）条件的相位约定等一系列优化来设计优化的SSE RF脉冲，以满足穿通动脉成像需求。在10 min内获得了各向同性0.30mm的高分辨率脑纹动脉（LSA）黑血图像.采用IV-SPACE序列对LSA管腔和管壁同时成像。通过优化的RF脉冲获得的图像比传统脉冲具有更少的来自ROI外部的混叠伪影。IV-SPACE图像显示LSA的血管壁和管腔比常规SPACE图像更清晰。IV-SPACE可能是一种很有前途的检测脑血管疾病微血管病变的方法。
The impairment of microvessels can lead to neurologic diseases such as stroke and vascular dementia. The imaging of lumen and vessel wall of perforating arteries requires an extremely high resolution due to their small caliber size. Current imaging techniques have the difficulty in observing the wall of perforating arteries. In this study, we developed a 3D inner-volume (IV) TSE (SPACE) sequence with optimized 2D spatially selective excitation (SSE) RF pulses. The optimized SSE RF pulses were designed through a series of optimization including iterative RF pulse design, trajectory optimization, and phase convention of Carr-Purcell-Meiboom-Gill (CPMG) condition to meet the perforating arteries imaging demands. High resolution of isotropic 0.30 mm within 10 min was achieved for the black- blood images of lenticulostriate artery (LSA). The LSA lumen and vessel wall were imaged by the IV-SPACE sequence simultaneously. Images obtained by the optimized RF pulse has fewer aliasing artifacts from outside of ROI than the traditional pulse. The IV-SPACE images showed clearer delineation of vessel wall and lumen of LSA than conventional SPACE images. IV-SPACE might be a promising method for detecting microvasculopathies of cerebral vascular diseases.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1007/s10334-016-0531-x
发表时间：
2016-06-01
影响因子：
2.3
作者：
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通讯作者：
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