Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer.
Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer.
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CXCR4 的过表达与顺铂化疗耐药显着相关，可能是上皮性卵巢癌的预后因素
DOI：
10.5483/bmbrep.2014.47.1.069
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发表时间：
2014-01
期刊：
影响因子：
3.8
通讯作者：
Xin X
中科院分区：
文献类型：
--
作者：
Li J;Jiang K;Qiu X;Li M;Hao Q;Wei L;Zhang W;Chen B;Xin X
趋化因子受体4（CXCR 4）在包括上皮性卵巢癌（EOC）在内的多种癌症的生长、血管生成和转移中起重要作用。然而，CXCR 4与EOC患者对化疗的临床反应之间的相关性仍然未知。招募124例EOC患者，以评估CXCR 4与顺铂为基础的化疗反应的关系。结果显示，与CXCR 4表达较低的患者相比，CXCR 4表达较高的患者具有显著较低的化疗敏感性，较差的无进展生存期和较低的总生存期。此外，通过小干扰RNA敲低CXCR 4抑制细胞增殖，并导致G1/S期阻滞，增加细胞凋亡和顺铂耐药细胞A2780/cis在体外的化疗敏感性。我们的数据表明，CXCR 4是EOC患者顺铂化疗的关键分子之一，CXCR 4抑制是解决EOC化疗耐药性的潜在策略。[BMB报告2014; 47（1）：33-38]
The chemokine receptor 4 (CXCR4) plays an important role in the growth, angiogenesis and metastasis of various cancers, including epithelial ovarian cancer (EOC). However, the correlation between CXCR4 and the clinical response of EOC patients to chemotherapy remains unknown. 124 EOC patients were recruited to assess the relationship between CXCR4 and the response to cisplatin-based chemotherapy. The results showed that patients with a higher CXCR4 expression had a significantly lower chemosensitivity, a poorer progression-free survival and a lower overall survival than those with lower CXCR4 expression. In addition, knockdown of CXCR4 by small interfering RNA suppressed cell proliferation and resulted in G1/S arrest, increased apoptosis and chemosensitivity in both cisplatin-sensitive A2780 cells and cisplatin-resistant cell A2780/cis in vitro. Our data suggest that CXCR4 is one of the key molecules in cisplatin-based chemotherapy for EOC patients and that CXCR4 inhibition is a potential strategy to address the chemoresistance of EOC. [BMB Reports 2014; 47(1): 33-38]
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影响因子：
7.4
作者：
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影响因子：
14
作者：
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影响因子：
3.7
作者：
Kim J;Yip ML;Shen X;Li H;Hsin LY;Labarge S;Heinrich EL;Lee W;Lu J;Vaidehi N
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影响因子：
11.5
作者：
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