Metabolic actions of Rho-kinase in periphery and brain.
Metabolic actions of Rho-kinase in periphery and brain.
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DOI：
10.1016/j.tem.2013.06.003
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发表时间：
2013-10
影响因子：
10.9
通讯作者：
Kim, Young-Bum
中科院分区：
文献类型：
--
作者：
Huang, Hu;Lee, Dae-Ho;Zabolotny, Janice M.;Kim, Young-Bum
近年来，肥胖以惊人的速度增长，现在已成为一个全球性的公共卫生问题。阐明与肥胖相关的代谢功能障碍背后的机制是当务之急。rho激酶（ROCK）的代谢功能在代谢相关疾病中一直是大量研究的主题。似乎抑制ROCK活性对多种心血管相关疾病的治疗是有益的。然而，最近对ROCK遗传模型的研究表明，ROCK在胰岛素和瘦素信号传导中起积极作用。在这里，我们讨论了新发现的ROCK在调节葡萄糖和能量代谢中的功能，特别强调了胰岛素和瘦素的代谢作用。
Obesity has increased at an alarming rate in recent years and is now a worldwide public health problem. Elucidating the mechanisms behind the metabolic dysfunctions associated with obesity is of high priority. The metabolic function of Rho-kinase (ROCK) has been the subject of a great deal of investigation in metabolic-related diseases. It appears that inhibition of ROCK activity is beneficial for the treatment of a wide range of cardiovascular-related diseases. However, recent studies with genetic models of ROCK demonstrate that ROCK plays a positive role in insulin and leptin signaling. Here we discuss the newly identified functions of ROCK in regulating glucose and energy metabolism, with particularly emphasis on metabolic actions of insulin and leptin.
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影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK
影响因子：
4.8
作者：
Chun, Kwang-Hoon;Araki, Kazushi;Kim, Young-Bum
通讯作者：
Kim, Young-Bum
影响因子：
25
作者：
Huang, Hu;Kong, Dong;Byun, Kyung Hee;Ye, Chianping;Koda, Shuichi;Lee, Dae Ho;Oh, Byung-Chul;Lee, Sam W.;Lee, Bonghee;Zabolotny, Janice M.;Kim, Min Seon;Bjorbaek, Christian;Lowell, Bradford B.;Kim, Young-Bum
通讯作者：
Kim, Young-Bum
影响因子：
4.8
作者：
de Wall, Esther Van;Leshan, Rebecca;Chua, Streamson C.
通讯作者：
Chua, Streamson C.
影响因子：
9.8
作者：
Finlayson, CA;Chappell, J;Draznin, B
通讯作者：
Draznin, B