Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers.
Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers.
复制标题
头颈癌患者低镁血症和放射性骨坏死的发生率。
DOI：
10.1002/hed.26510
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发表时间：
2021-02
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
我们的目的是确定低镁血症是否可以预测接受铂类同步放化疗（联合或不联合诱导治疗）的口咽和口腔鳞状细胞癌患者发生放射性骨坏死。我们回顾了2010年1月1日至2014年12月31日期间在我们机构接受每周顺铂/卡铂化放疗的头颈癌患者的数据。记录病理特征、实验室检查结果、疾病阶段和社会史。控制已知的混杂因素，分析低镁血症和放射性骨坏死之间的关联。在接受铂类诱导化疗随后同步放化疗的患者中，癌症治疗期间的低镁血症与放射性骨坏死的发生相关（HR = 2.72，P = .037），与总辐射剂量（HR = 1.07，P = .260）和吸烟史（HR = 2.05，P = .056）无关。接受铂类诱导和同步放化疗的口咽癌和口腔癌患者中，低镁血症可预测放射性骨坏死的发生。
We aimed to determine whether hypomagnesemia predicts osteoradionecrosis development in patients with squamous cell carcinoma of the oropharynx and oral cavity who received platinum-based concurrent chemoradiation with or without induction therapy. We reviewed data from patients with head and neck cancers who had undergone chemoradiation with weekly cisplatin/carboplatin between January 1, 2010 and December 31, 2014 at our institution. Pathologic features, laboratory test results, disease stage, and social histories were recorded. The association between hypomagnesemia and osteoradionecrosis was analyzed controlling for known confounding factors. Hypomagnesemia during cancer treatment was associated with osteoradionecrosis development (HR = 2.72, P = .037) independent of total radiation dose (HR = 1.07, P = .260) and smoking history (HR = 2.05, P = .056) among the patients who received platinum-based induction chemotherapy followed by concurrent chemoradiation. Hypomagnesemia was predictive of the development of osteoradionecrosis in patients with cancers of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation.
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DOI：
10.1016/s0360-3016(02)03819-1
发表时间：
2003-01-01
影响因子：
7
作者：
Denis, F;Garaud, P;Calais, G
通讯作者：
Calais, G
影响因子：
13.2
作者：
LAM, M;ADELSTEIN, DJ
通讯作者：
ADELSTEIN, DJ
影响因子：
13.6
作者：
Kunutsor, Setor Kwadzo;Whitehouse, Michael Richard;Laukkanen, Jari Antero
通讯作者：
Laukkanen, Jari Antero
影响因子：
51.1
作者：
Tejpar, Sabine;Piessevaux, Hubert;Van Cutsem, Eric
通讯作者：
Van Cutsem, Eric
影响因子：
7.1
作者：
Orchard, Tonya S.;Larson, Joseph C.;Jackson, Rebecca D.
通讯作者：
Jackson, Rebecca D.