Src as the link between inflammation and cancer.
Src as the link between inflammation and cancer.
复制标题
DOI：
10.3389/fphys.2013.00416
复制
发表时间：
2013
影响因子：
4
通讯作者：
Ptasznik A
中科院分区：
文献类型：
--
作者：
Liu ST;Pham H;Pandol SJ;Ptasznik A
尽管慢性炎症和癌症之间的因果关系已经确定，但将炎症和癌症联系起来的确切分子机制在很大程度上仍不清楚。以前的假设是，负责癌细胞发展和炎性细胞向癌细胞渗透的分子开关被分为一组不同的细胞内蛋白质和信号通路。然而，最近的证据表明，肿瘤细胞和肿瘤浸润性免疫细胞都利用相同的激酶，主要是Src家族的蛋白，以促进癌症的发生和发展。在过去的几年里，几个研究小组发现，在癌症和炎症细胞中，Src的激活主要是由肿瘤微环境中的促炎细胞因子驱动的。在这里，我们评估了免疫细胞和癌细胞中的Src激酶通路之间的相互作用。我们得出结论，src可能作为炎症和癌症之间的关键机制联系，在免疫细胞和组织细胞之间调节和传播一个循环，最终导致癌症的发生和发展。
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown. It was previously postulated that molecular switches responsible for cancer cell development, and for infiltration of inflammatory cells into cancer, were divided into a distinct set of intracellular proteins and signaling pathways. However, recent evidence suggests that both tumor cells and tumor-infiltrating immune cells utilize the same kinases, mostly that of Src family, to facilitate cancer development and progression. In the past few years several groups have found that Src activation both in cancer and inflammatory cells is mainly driven by pro-inflammatory cytokines within the tumor microenvironment. Here we evaluate the cross talks between Src kinase pathways in immune cells and cancer cells. We conclude that Src might serve as a critical mechanistic link between inflammation and cancer, mediating and propagating a cycle between immune and tissue cells that can ultimately lead to the development and progression of cancer.
登录
查看更多内容
DOI：
10.1083/jcb.200304153
发表时间：
2003-11-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kayali AG;Van Gunst K;Campbell IL;Stotland A;Kritzik M;Liu G;Flodström-Tullberg M;Zhang YQ;Sarvetnick N
通讯作者：
Sarvetnick N
影响因子：
5.5
作者：
Cheung, Ricky;Malik, Mobeen;Collman, Ronald G.
通讯作者：
Collman, Ronald G.
影响因子：
3.8
作者：
Goecke, H;Forssmann, U;Büchler, MW
通讯作者：
Büchler, MW
影响因子：
3.6
作者：
Gao, Zhenjun;Wang, Xingpeng;Hu, Guoyong
通讯作者：
Hu, Guoyong
影响因子：
6.2
作者：
Allgayer, H;Boyd, DD;Gallick, GE
通讯作者：
Gallick, GE