Lactate as a Metabolite and a Regulator in the Central Nervous System.
Lactate as a Metabolite and a Regulator in the Central Nervous System.
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DOI：
10.3390/ijms17091450
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发表时间：
2016-09-01
影响因子：
5.6
通讯作者：
Di Liegro I
中科院分区：
文献类型：
--
作者：
Proia P;Di Liegro CM;Schiera G;Fricano A;Di Liegro I
在乳酸盐被发现200多年后，它仍然是一种令人着迷的分子。长期以来，人们一直认为它是新陈代谢的废物，是肌肉疲劳的罪魁祸首，后来人们认识到它是许多细胞的重要燃料。特别是在神经系统中，有人提出星形胶质细胞响应神经元激活而释放的乳酸被神经元吸收，氧化为丙酮酸，用于合成乙酰辅酶a，用于三羧酸循环。最近，除了这种代谢作用之外，一种特殊受体的发现促使人们重新考虑它的作用，乳酸盐现在被视为一种激素，甚至参与记忆形成和神经保护等复杂的过程。事实上，运动对我们的机体有很多好处，似乎可以延缓大脑老化和神经退化。现在，运动诱导乳酸的产生和释放到血液中，乳酸可以到达肝脏，心脏，还有大脑。乳酸是运动过程中产生的有益分子，并提供神经保护吗？在这篇综述中，我们总结了我们对乳酸盐的了解，讨论了这种分子随着时间的推移所起的作用。
More than two hundred years after its discovery, lactate still remains an intriguing molecule. Considered for a long time as a waste product of metabolism and the culprit behind muscular fatigue, it was then recognized as an important fuel for many cells. In particular, in the nervous system, it has been proposed that lactate, released by astrocytes in response to neuronal activation, is taken up by neurons, oxidized to pyruvate and used for synthesizing acetyl-CoA to be used for the tricarboxylic acid cycle. More recently, in addition to this metabolic role, the discovery of a specific receptor prompted a reconsideration of its role, and lactate is now seen as a sort of hormone, even involved in processes as complex as memory formation and neuroprotection. As a matter of fact, exercise offers many benefits for our organisms, and seems to delay brain aging and neurodegeneration. Now, exercise induces the production and release of lactate into the blood which can reach the liver, the heart, and also the brain. Can lactate be a beneficial molecule produced during exercise, and offer neuroprotection? In this review, we summarize what we have known on lactate, discussing the roles that have been attributed to this molecule over time.
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影响因子：
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作者：
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通讯作者：
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