Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors.
Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors.
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DOI：
10.3389/fnbeh.2022.801825
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发表时间：
2022
影响因子：
3
通讯作者：
Silberman Y
中科院分区：
文献类型：
--
作者：
Keller BN;Hajnal A;Browning KN;Arnold AC;Silberman Y
调节酒精使用障碍（AUD）的发展和维持的神经生物学机制是复杂的，涉及各种系统内和系统间的神经适应。虽然经典的奖励，专注和戒断神经回路已经在AUD方面进行了大量研究，但这些文献中的可行治疗目标尚未证明临床有效。因此，在AUD背景下未进行经典研究的其他神经回路检查可能提供新的治疗靶点。最近的研究表明，各种神经肽系统是酒精奖励，寻求和摄入行为的重要调节剂。这包括背侧迷走神经复合体（DVC）内的神经回路，其参与自主神经系统的控制、自然奖赏（如食物）的摄入的控制，并且通过许多肠-脑肽和神经递质系统与DVC投射到中枢和外周靶点的相互作用充当内感受性感觉信息的中继。DVC神经元亚型产生各种神经肽和递质，并投射到对奖赏至关重要的脑区域，如中脑边缘多巴胺系统以及对酒精戒断的负面强化和厌恶性质重要的其他边缘区域，如扩展杏仁核。这表明DVC可能在AUD的各个方面的调制中发挥作用。本文综述了目前有关DVC中神经递质和神经肽系统的文献（例如，去甲肾上腺素、胰高血糖素样肽1、神经降压素、胆囊收缩素、促甲状腺素释放激素），以及它们与用于AUD研究的人类和啮齿动物模型中的酒精相关行为的潜在相关性。更好地了解DVC在调节酒精相关行为中的作用可能会导致对AUD药物开发的新治疗靶点的阐明。
The neurobiological mechanisms that regulate the development and maintenance of alcohol use disorder (AUD) are complex and involve a wide variety of within and between systems neuroadaptations. While classic reward, preoccupation, and withdrawal neurocircuits have been heavily studied in terms of AUD, viable treatment targets from this established literature have not proven clinically effective as of yet. Therefore, examination of additional neurocircuitries not classically studied in the context of AUD may provide novel therapeutic targets. Recent studies demonstrate that various neuropeptides systems are important modulators of alcohol reward, seeking, and intake behaviors. This includes neurocircuitry within the dorsal vagal complex (DVC), which is involved in the control of the autonomic nervous system, control of intake of natural rewards like food, and acts as a relay of interoceptive sensory information via interactions of numerous gut-brain peptides and neurotransmitter systems with DVC projections to central and peripheral targets. DVC neuron subtypes produce a variety of neuropeptides and transmitters and project to target brain regions critical for reward such as the mesolimbic dopamine system as well as other limbic areas important for the negative reinforcing and aversive properties of alcohol withdrawal such as the extended amygdala. This suggests the DVC may play a role in the modulation of various aspects of AUD. This review summarizes the current literature on neurotransmitters and neuropeptides systems in the DVC (e.g., norepinephrine, glucagon-like peptide 1, neurotensin, cholecystokinin, thyrotropin-releasing hormone), and their potential relevance to alcohol-related behaviors in humans and rodent models for AUD research. A better understanding of the role of the DVC in modulating alcohol related behaviors may lead to the elucidation of novel therapeutic targets for drug development in AUD.
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影响因子：
9.3
作者：
Bonnet, Marion S.;Pecchi, Emilie;Troadec, Jean-Denis
通讯作者：
Troadec, Jean-Denis
影响因子：
4.8
作者：
Appleyard, SM;Hayward, M;Low, MJ
通讯作者：
Low, MJ
影响因子：
2.9
作者：
Antonsen KK;Klausen MK;Brunchmann AS;le Dous N;Jensen ME;Miskowiak KW;Fisher PM;Thomsen GK;Rindom H;Fahmy TP;Vollstaedt-Klein S;Benveniste H;Volkow ND;Becker U;Ekstrøm C;Knudsen GM;Vilsbøll T;Fink-Jensen A
通讯作者：
Fink-Jensen A
DOI：
10.1097/med.0b013e3280122850
发表时间：
2007-02-01
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Chandra, Rashmi;Liddle, Rodger A
通讯作者：
Liddle, Rodger A
影响因子：
3.3
作者：
Bienkowski, M. S.;Rinaman, L.
通讯作者：
Rinaman, L.