Polycystic ovary syndrome: do endocrine-disrupting chemicals play a role?
Polycystic ovary syndrome: do endocrine-disrupting chemicals play a role?
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DOI：
10.1055/s-0034-1371088
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发表时间：
2014-05
影响因子：
2.7
通讯作者：
Sobolewski M
中科院分区：
文献类型：
--
作者：
Barrett ES;Sobolewski M
多囊卵巢综合征（PCOS）是一种以多种内分泌紊乱为特征的异质性疾病，其根本原因虽然不确定，但可能是遗传和环境的。最近，人们对环境中的内分泌干扰物（EDCs），特别是双酚A（BPA）是否可能导致这种疾病产生兴趣。在动物模型中，在围产期暴露于BPA会显著破坏女性的卵巢和生殖功能，通常剂量与人类暴露的典型水平相似。BPA似乎也有致肥胖的特性，扰乱正常的代谢活动，使身体容易超重。在人类中，横断面数据表明，多囊卵巢综合征妇女的BPA浓度高于生殖健康妇女，但因果关系的方向尚未确定。由于这项研究尚处于起步阶段，需要开展更多的工作来了解内分泌干扰物可能导致PCOS的机制以及暴露的关键时期，甚至可能是跨代的。未来的研究还应该把重点放在将动物模型中有前途的工作转化为纵向人体研究，并确定除了BPA之外，其他的内分泌干扰物是否值得考虑。
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by multiple endocrine disturbances and its underlying causes, although uncertain, are likely to be both genetic and environmental. Recently, there has been interest in whether endocrine disrupting chemicals (EDCs) in the environment, particularly Bisphenol A (BPA), may contribute to the disorder. In animal models, exposure to BPA during the perinatal period, dramatically disrupts ovarian and reproductive function in females, often at doses similar to typical levels of human exposure. BPA also appears to have obesogenic properties, disrupting normal metabolic activity and making the body prone to overweight. In humans, cross-sectional data suggests that BPA concentrations are higher in women with PCOS than in reproductively healthy women, but the direction of causality has not been established. As this research is in its infancy, additional work is needed to understand the mechanisms by which EDCs may contribute to PCOS as well as the critical periods of exposure, which may even be transgenerational. Future research should also focus on translating the promising work in animal models into longitudinal human studies and determining whether additional EDCs, beyond BPA, may be important to consider.
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DOI：
10.1016/j.reprotox.2013.07.017
发表时间：
2013-12
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Angle BM;Do RP;Ponzi D;Stahlhut RW;Drury BE;Nagel SC;Welshons WV;Besch-Williford CL;Palanza P;Parmigiani S;vom Saal FS;Taylor JA
通讯作者：
Taylor JA
影响因子：
3.7
作者：
Dasgupta S;Sirisha PV;Neelaveni K;Anuradha K;Reddy AG;Thangaraj K;Reddy BM
通讯作者：
Reddy BM
影响因子：
10.4
作者：
Fernández M;Bourguignon N;Lux-Lantos V;Libertun C
通讯作者：
Libertun C
雌激素受体ERα调节胰腺胰岛素含量。
影响因子：
3.7
作者：
Alonso-Magdalena, Paloma;Ropero, Ana B.;Carrera, M. Pilar;Cederroth, Christopher R.;Baquie, Mathurin;Gauthier, Benoit R.;Nef, Serge;Stefani, Enrico;Nadal, Angel
通讯作者：
Nadal, Angel
影响因子：
3.7
作者：
Batista TM;Alonso-Magdalena P;Vieira E;Amaral ME;Cederroth CR;Nef S;Quesada I;Carneiro EM;Nadal A
通讯作者：
Nadal A