Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.
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DOI：
10.1016/j.reprotox.2013.07.017
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Taylor JA
中科院分区：
文献类型：
--
作者：
Angle BM;Do RP;Ponzi D;Stahlhut RW;Drury BE;Nagel SC;Welshons WV;Besch-Williford CL;Palanza P;Parmigiani S;vom Saal FS;Taylor JA
暴露于双酚A （BPA）与人类和实验动物代谢疾病的许多方面有关。我们以5 ~ 50,000 μg/kg/d的剂量给怀孕的CD-1小鼠喂食BPA，剂量范围为参考剂量的10倍到目前预测的无不良反应水平（NOAEL）的10倍。当BPA剂量低于NOAEL时，胎儿血清（AUC0-24h）中平均未共轭BPA在2 - 200pg/ml之间，我们观察到对成年雄性后代的显著影响：食物摄入量的年龄相关变化，体重和肝脏重量，腹部脂肪细胞质量，数量和体积以及血清瘦素和胰岛素的增加，但血清脂联素和葡萄糖耐量下降。对于大多数这些结果，观察到非单调的剂量-反应关系；BPA的最高剂量并没有对任何结果产生显著影响。0.1 μg/kg/天的DES剂量会导致部分低剂量BPA结果，但不是全部。
Exposure to bisphenol A (BPA) is implicated in many aspects of metabolic disease in humans and experimental animals. We fed pregnant CD-1 mice BPA at doses ranging from 5 to 50,000 μg/kg/day, spanning 10-fold below the reference dose to 10-fold above the currently predicted no adverse effect level (NOAEL). At BPA doses below the NOAEL that resulted in average unconjugated BPA between 2 and 200pg/ml in fetal serum (AUC0–24h),we observed significant effects in adult male offspring: an age-related change in food intake, an increase in body weight and liver weight, abdominal adipocyte mass, number and volume, and in serum leptin and insulin, but a decrease in serum adiponectin and in glucose tolerance. For most of these outcomes non-monotonic dose–response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome. A 0.1-μg/kg/day dose of DES resulted in some but not all low-dose BPA outcomes.
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影响因子：
10.4
作者：
Alonso-Magdalena P;Vieira E;Soriano S;Menes L;Burks D;Quesada I;Nadal A
通讯作者：
Nadal A
影响因子：
4
作者：
Aghajanova, L.;Giudice, L. C.
通讯作者：
Giudice, L. C.
影响因子：
10.4
作者：
Birnbaum LS;Bucher JR;Collman GW;Zeldin DC;Johnson AF;Schug TT;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
3.4
作者：
Adewale HB;Todd KL;Mickens JA;Patisaul HB
通讯作者：
Patisaul HB
DOI：
10.1046/j.1525-1373.2000.22402.x
发表时间：
2000-06-01
影响因子：
--
作者：
Gupta, C
通讯作者：
Gupta, C