Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial.
Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial.
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DOI：
10.3389/fnagi.2023.1266423
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发表时间：
2023
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
非裔美国人被诊断患有阿尔茨海默病（AD）的可能性是美国白人的两到三倍。运动是一种与神经保护和降低AD风险相关的生活方式行为，尽管大多数非裔美国人，尤其是老年人，每周进行的中等至高强度运动少于建议的150分钟。本文描述了一项III期随机对照试验的方案，该试验将检查有氧有氧运动对阿尔茨海默病新认知和海马依赖功能的神经标志物的影响（目的1和2），以及运动诱导的神经保护益处是否可能由阿尔茨海默病遗传风险因子ABCA7 rs3764650（目的3）调节。我们还将探讨运动对阿尔茨海默病血液生物标志物的影响。这项为期6个月的试验将包括280名非洲裔美国人（≥60岁），他们将被随机分配到3天/周：(1)中等到高强度的有氧舞蹈健身条件或(2)低强度的力量、柔韧性和平衡条件，每次60分钟。在研究开始和6个月时，参与者将完成健康和行为调查、神经心理测试、唾液和静脉穿刺、有氧健身、人体测量和静息状态结构和功能神经成像。这项调查的结果将为未来的运动试验和旨在降低非裔美国人患AD风险的处方干预措施的发展提供信息。
African Americans are two to three times more likely to be diagnosed with Alzheimer’s disease (AD) compared to White Americans. Exercise is a lifestyle behavior associated with neuroprotection and decreased AD risk, although most African Americans, especially older adults, perform less than the recommended 150 min/week of moderate-to-vigorous intensity exercise. This article describes the protocol for a Phase III randomized controlled trial that will examine the effects of cardio-dance aerobic exercise on novel AD cognitive and neural markers of hippocampal-dependent function (Aims #1 and #2) and whether exercise-induced neuroprotective benefits may be modulated by an AD genetic risk factor, ABCA7 rs3764650 (Aim #3). We will also explore the effects of exercise on blood-based biomarkers for AD. This 6-month trial will include 280 African Americans (≥ 60 years), who will be randomly assigned to 3 days/week of either: (1) a moderate-to-vigorous cardio-dance fitness condition or (2) a low-intensity strength, flexibility, and balance condition for 60 min/session. Participants will complete health and behavioral surveys, neuropsychological testing, saliva and venipuncture, aerobic fitness, anthropometrics and resting-state structural and functional neuroimaging at study entry and 6 months. Results from this investigation will inform future exercise trials and the development of prescribed interventions that aim to reduce the risk of AD in African Americans.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4
作者：
Baker, Laura D.;Frank, Laura L.;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
5.3
作者：
Adlard, PA;Perreau, VM;Cotman, CW
通讯作者：
Cotman, CW
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.