Inhibitory Role of Pentraxin-3 in Esophageal Squamous Cell Carcinoma.
Inhibitory Role of Pentraxin-3 in Esophageal Squamous Cell Carcinoma.
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Pentraxin-3对食管鳞状细胞癌的抑制作用
DOI：
10.4103/0366-6999.189921
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发表时间：
2016-09-20
影响因子：
6.1
通讯作者：
Zhang ST
中科院分区：
文献类型：
--
作者：
Ma D;Zong Y;Zhu ST;Wang YJ;Li P;Zhang ST
背景：食管癌是世界范围内癌症相关死亡的第六大原因。Pentraxin-3（PTX 3）是PTX超家族的成员。在此，我们研究了PTX 3在食管鳞状细胞癌（ESCC）中的作用。方法：采用细胞活力测定、集落形成测定、流式细胞术以及迁移和侵袭测定来研究PTX 3对ESCC细胞增殖、集落形成、凋亡、迁移和侵袭的影响。通过裸鼠移植瘤研究PTX 3对ESCC体内致瘤性的影响。结果：PTX 3过表达可抑制食管鳞癌细胞的增殖和集落形成（P < 0.05），增加凋亡率（P < 0.05）。PTX 3表达对ESCC细胞的迁移或侵袭能力没有显著影响。在我们的人ESCC小鼠模型中，我们实现了100%成功的肿瘤建立。与对照组和空载体表达组相比，PTX 3表达组形成的肿瘤显著更小（P < 0.05）。结论：PTX 3可能在食管鳞癌中起抑制作用。
Background:Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Pentraxin-3 (PTX3) is a member of the PTX superfamily. Here, we investigated the role of PTX3 in esophageal squamous cell carcinoma (ESCC). Methods:The effect of PTX3 on ESCC cell proliferation, colony formation, apoptosis, migration, and invasion was investigated using cell viability assays, colony formation assays, flow cytometry, and migration and invasion assays. The effect of PTX3 on the tumorigenicity of ESCC in vivo was investigated with xenograft studies in nude mice. Results:PTX3 overexpression in ESCC cells reduced cellular proliferation and colony formation (P < 0.05) and increased the rate of apoptosis (P < 0.05). PTX3 expression had no significant effect on the migratory or invasive potential of ESCC cells. In our mouse model of human ESCC, we achieved 100% successful tumor establishment. Compared with the control and empty vector-expressing groups, the PTX3-expressing group formed significantly smaller tumors (P < 0.05). Conclusions:This study indicates that PTX3 might play an inhibitory role in ESCC.
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影响因子：
--
作者：
Choi B;Lee EJ;Song DH;Yoon SC;Chung YH;Jang Y;Kim SM;Song Y;Kang SW;Yoon SY;Chang EJ
通讯作者：
Chang EJ
影响因子：
37.8
作者：
Latini, R;Maggioni, AP;Mantovani, A
通讯作者：
Mantovani, A
影响因子：
4.3
作者：
Wang, Jun-Xiong;He, Yuan-Long;Zhang, Shu-Tian
通讯作者：
Zhang, Shu-Tian
影响因子：
4.4
作者：
Bussolati, B;Peri, G;Camussi, G
通讯作者：
Camussi, G
影响因子：
7.3
作者：
Ronca, Roberto;Alessi, Patrizia;Presta, Marco
通讯作者：
Presta, Marco