Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function.
Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function.
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DOI：
10.18632/oncotarget.1664
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发表时间：
2014-01-30
期刊：
影响因子：
--
通讯作者：
Chang EJ
中科院分区：
文献类型：
--
作者：
Choi B;Lee EJ;Song DH;Yoon SC;Chung YH;Jang Y;Kim SM;Song Y;Kang SW;Yoon SY;Chang EJ
正五聚蛋白3（PTX 3）是一种肿瘤相关炎症的调节剂，已知与肿瘤分级和恶性肿瘤的严重程度正相关，但其确切作用尚不清楚。这项研究发现，与64名人类乳腺癌患者的肺、肝和脑转移相比，乳腺癌远端骨转移中PTX 3表达上调。PTX3的高表达与乳腺癌患者的生存率相关。在骨转移性乳腺癌细胞系中，PTX 3的表达也上调，并通过促炎细胞因子TNFα进一步增强。PTX 3的施用促进了乳腺癌细胞的迁移潜力和巨噬细胞（破骨细胞（OC）的前体）向乳腺癌细胞的动员。此外，TNFα诱导的PTX 3表达增加导致OC形成增加，提示PTX 3在乳腺癌细胞溶骨性骨转移中的独特作用。此外，使用siRNA特异性siRNA的PTX 3沉默阻止了乳腺癌细胞迁移、巨噬细胞趋化性和随后的OC形成。这些发现为PTX 3在乳腺癌炎症相关溶骨性并发症中的关键作用提供了重要的见解。
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases of breast cancer compared to lung, liver, and brain metastases in 64 human breast cancer patients. Elevated expression of PTX3 was correlated with poor survival in patients with breast cancer. PTX3 expression was also up-regulated in a bone metastatic breast cancer cell line and further enhanced by pro-inflammatory cytokine TNFα. Administration of PTX3 promoted the migratory potential of breast cancer cells and the mobilization of macrophages, a precursor of osteoclasts (OCs), toward breast cancer cells. In addition, elevated expression of PTX3 by TNFα led to enhanced OC formation, implying the distinct role of PTX3 in osteolytic bone metastasis of breast cancer cells. Furthermore, PTX3 silencing using siRNA-specific siRNA prevented breast cancer cell migration, macrophage Chemotaxis, and subsequent OC formation. These findings provide an important insight into the key role of PTX3 in inflammation-associated osteolytic complications of breast cancer.
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影响因子：
11.2
作者：
Germano, Giovanni;Frapolli, Roberta;Allavena, Paola
通讯作者：
Allavena, Paola
影响因子：
11.5
作者：
Coleman, Robert E.
通讯作者：
Coleman, Robert E.
影响因子：
5.5
作者：
Bottazzi, Barbara;Bastone, Antonio;Mantovani, Alberto
通讯作者：
Mantovani, Alberto
影响因子：
4.1
作者：
Jiang X;Shapiro DJ
通讯作者：
Shapiro DJ
DOI：
10.1084/jem.20061301
发表时间：
2007-04-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jaillon S;Peri G;Delneste Y;Frémaux I;Doni A;Moalli F;Garlanda C;Romani L;Gascan H;Bellocchio S;Bozza S;Cassatella MA;Jeannin P;Mantovani A
通讯作者：
Mantovani A