Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9.
Elevated body mass disrupts the barrier to gastroesophageal reflux; discussion 1018-9.
复制标题
体重增加会破坏胃食管反流的屏障；
作者：
S. Wajed;C. Streets;C. Bremner;T. Demeester
假设
肥胖损害了结构完整的屏障的抗反流功能。
设计
食管测压结果正常但有症状且客观证实胃食管反流患者的体重指数的回顾性分析。
设置
食道专科中心。
患者
1998年10月1日至2000年6月30日期间转诊的有胃食管反流症状和诊断的患者。排除标准为屏障缺陷、运动障碍或既往手术史。
主要观察指标
使用DeMeester评分定义和量化反流，并计算体重指数。
结果
体重指数与胃食管反流的严重程度有很强的相关性。超重患者的远端食管酸暴露显著较高。正常体重和超重患者的测压结果无显著差异。
结论
超重患者的胃食管反流屏障不足。
HYPOTHESIS
Obesity impairs the antireflux function of a structurally intact barrier.
DESIGN
Retrospective analysis of body mass index in patients with normal esophageal manometric findings but with symptomatic and objectively confirmed gastroesophageal reflux.
SETTING
Specialist esophageal center.
PATIENTS
Patients symptomatic and diagnostic for gastroesophageal reflux, referred between October 1, 1998, and June 30, 2000. Exclusion criteria were a defective barrier, motility disorders, or previous surgery.
MAIN OUTCOME MEASURES
Reflux was defined and quantified using the DeMeester score, and body mass index was calculated.
RESULTS
There was a strong correlation between body mass index and severity of gastroesophageal reflux. Patients who were overweight had significantly higher distal esophageal acid exposure. No significant difference in manometric findings was demonstrated between patients with normal weight and those who were overweight.
CONCLUSION
The barrier to gastroesophageal reflux is rendered insufficient in patients who are overweight.
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影响因子：
9
作者：
Stein,HJ;Barlow,AP;DeMeester,TR;Hinder,RA
通讯作者：
Hinder,RA
影响因子：
158.5
作者：
Lagergren, J;Bergström, R;Nyrén, O
通讯作者：
Nyrén, O
影响因子：
5.9
作者：
Locke, GR;Talley, NJ;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
158.5
作者：
DODDS, WJ;DENT, J;EGIDE, MS
通讯作者：
EGIDE, MS