Exposure to traffic pollution and increased risk of rheumatoid arthritis.
Exposure to traffic pollution and increased risk of rheumatoid arthritis.
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DOI：
10.1289/ehp.0800503
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
Karlson EW
中科院分区：
文献类型：
--
作者：
Hart JE;Laden F;Puett RC;Costenbader KH;Karlson EW
风湿性关节炎（RA）是一种慢性全身性炎症性疾病，影响约1%的成年人群，迄今为止，遗传因素解释了< 50%的风险。颗粒空气污染，特别是交通来源，在许多研究中与全身炎症有关。我们在一项前瞻性队列研究中研究了与道路距离（交通污染暴露的标志物）和类风湿关节炎发病率之间的关系。我们在护士健康研究中研究了90，297名美国女性。我们使用地理信息系统来确定2000年住宅与道路的距离，作为交通暴露的衡量标准。使用考克斯比例风险模型，我们研究了距离道路和事件RA（1976-2004年）的关联，调整了大量的潜在混杂因素。在调整了年龄、历年、种族、吸烟、产次、哺乳期、绝经状态和激素使用、口服避孕药使用、体重指数、体力活动、人口普查水平的中位数收入和房屋价值的模型中，我们观察到RA的风险升高[风险比（HR）= 1.31; 95%置信区间（CI），0.98-1.74]，与那些生活在200米或更远的妇女相比，生活在50米的道路。我们还在非吸烟者（HR = 1.62; 95%CI，1.04-2.52）、非吸烟者类风湿因子（RF）阴性RA（HR = 1.77; 95%CI，0.93-3.38）和非吸烟者RF阳性RA（HR = 1.51; 95%CI，0.82-2.77）的分析中观察到这种相关性。我们没有看到居住在离公路50-200米处的妇女的风险升高。暴露于交通污染和类风湿关节炎之间观察到的关联表明，污染的交通在成年可能是一个新确定的环境风险因素类风湿关节炎。
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that affects approximately 1% of the adult population, and to date, genetic factors explain < 50% of the risk. Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies. We examined the association of distance to road, a marker of traffic pollution exposure, and incidence of RA in a prospective cohort study. We studied 90,297 U.S. women in the Nurses’ Health Study. We used a geographic information system to determine distance to road at the residence in 2000 as a measure of traffic exposure. Using Cox proportional hazard models, we examined the association of distance to road and incident RA (1976–2004) with adjustment for a large number of potential confounders. In models adjusted for age, calendar year, race, cigarette smoking, parity, lactation, menopausal status and hormone use, oral contraceptive use, body mass index, physical activity, and census-tract-level median income and house value, we observed an elevated risk of RA [hazard ratio (HR) = 1.31; 95% confidence interval (CI), 0.98–1.74] in women living within 50 m of a road, compared with those women living 200 m or farther away. We also observed this association in analyses among nonsmokers (HR = 1.62; 95% CI, 1.04–2.52), nonsmokers with rheumatoid factor (RF)-negative RA (HR = 1.77; 95% CI, 0.93–3.38), and nonsmokers with RF-positive RA (HR = 1.51; 95% CI, 0.82–2.77). We saw no elevations in risk in women living 50–200 m from the road. The observed association between exposure to traffic pollution and RA suggests that pollution from traffic in adulthood may be a newly identified environmental risk factor for RA.
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影响因子：
10.4
作者：
Guo YL;Lin YC;Sung FC;Huang SL;Ko YC;Lai JS;Su HJ;Shaw CK;Lin RS;Dockery DW
通讯作者：
Dockery DW
影响因子：
--
作者：
Doran, MF;Pond, GR;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
27.4
作者：
HAZES, JMW;DIJKMANS, BAC;CATS, A
通讯作者：
CATS, A
DOI：
10.1038/sj.jea.7500388
发表时间：
2005-03-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Jerrett, M;Arain, A;Giovis, C
通讯作者：
Giovis, C
影响因子：
2.1
作者：
Adar, S. D.;Kaufman, J. D.
通讯作者：
Kaufman, J. D.