Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood.
Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood.
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DOI：
10.3390/ijerph15061066
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发表时间：
2018-05-24
影响因子：
--
通讯作者：
Liao YP
中科院分区：
文献类型：
--
作者：
Liu CY;Chen PC;Lien PC;Liao YP
背景：全氟烷基物质（PFASs）在环境、动物和人类中具有稳定性和持久性。PFASs可穿透胎盘，影响胎儿生长。我们研究了产前暴露于全氟辛酸（PFOA）、全氟辛基磺酸（PFOS）、全氟壬酸（PFNA）和全氟癸酸（PFUA）与全球甲基化水平之间的关系。具体目的与方法：本研究采用台湾出生队列研究的研究对象，包括2004年7月至2005年6月在台北市及新北市四家医院分娩的孕妇。总共有363对母婴被纳入最后的分析。采用UPLC-MS/MS法测定脐带血中PFOA、PFOS、PFNA和PFUA。来自脐带血的LINE-1和Alu重复元素被用来代表全球DNA甲基化水平。多变量回归模型用于调整潜在的混杂因素。结果：在控制了潜在的混杂因素后，对于低Alu甲基化水平，每单位自然对数转化的全氟辛烷磺酸暴露增加与调整OR为1.72 （95% CI: 1.03, 2.88）相关。在多变量回归模型中，PFOA、PFNA、PFUA与甲基化水平之间无显著影响。结论：我们的研究结果表明，产前全氟辛烷磺酸暴露可能与低Alu甲基化水平有关。
Background: Perfluoroalkyl substances (PFASs) are stable and persistent in the environment, animals, and humans. PFASs can penetrate placenta and affect fetal growth. We investigated associations between prenatal exposure to perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) and global methylation levels. Specific Aims and Methods: The study used the subjects from Taiwan Birth Panel birth cohort study, including all pregnant women who gave birth between July 2004 and June 2005 in four hospitals in Taipei city and New Taipei City. A total of 363 mother-infant pairs were included in the final analyses. PFOA, PFOS, PFNA, and PFUA were measured by UPLC-MS/MS in cord blood. LINE-1 and Alu repeated elements from cord blood was used to represent global DNA methylation levels. Multivariable regression models were used to adjust potential confounders. Results: After controlling for potential confounders, each unit increase in the natural log-transformed PFOS exposure was associated with an adjusted OR of 1.72 (95% CI: 1.03, 2.88) for low Alu methylation level when dichotomized methylation level by medium. No significant effects between PFOA, PFNA, PFUA and methylation levels in the multivariable regression models were observed. Conclusions: Our findings suggest that prenatal PFOS exposure may be associated with low Alu methylation level.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
2.8
作者：
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通讯作者：
Holland, Nina
DOI：
10.1016/j.mrgentox.2010.04.024
发表时间：
2010-07-19
影响因子：
1.9
作者：
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通讯作者：
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3.7
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影响因子：
10.7
作者：
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通讯作者：
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