Corollary discharge enables proprioception from lateral line sensory feedback.
Corollary discharge enables proprioception from lateral line sensory feedback.
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DOI：
10.1371/journal.pbio.3001420
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发表时间：
2021-10
期刊：
影响因子：
9.8
通讯作者：
Liao JC
中科院分区：
文献类型：
--
作者：
Skandalis DA;Lunsford ET;Liao JC
动物调节感觉处理与运动动作一致。运动信号的平行副本，称为必然放电（CD），使神经系统准备处理运动过程中出现的外部和自我产生（传入）反馈的混合物。通常，周围神经系统中的CD取消了传入，以保护传感器和中枢神经系统免受自我产生的反馈的疲劳和压倒。然而，抵消也限制了有助于动物意识到其身体位置和环境中的运动的反馈，即本体感觉。我们建议，而不是取消，CD到鱼侧线器官reafference，以最大限度地提高本体感受信息的内容。鱼类的波动性身体运动引起的传入反馈，可以编码的身体的瞬时配置相对于流体流动。我们结合了游泳生物力学和毛细胞生理学的实验和计算分析，开发了一个神经力学模型，用于研究鱼类如何跟踪峰值身体曲率，这是轴向波动运动的关键特征。如果没有CD，这种计算将受到感官适应的挑战，其典型表现为相对于输入刺激的灵敏度衰减和相位失真。我们发现，CD与传感器极化协同作用，使灵敏度沿沿着传感器的首选轴。灵敏度的锐化将尖峰调节到与峰值传入刺激相一致的窄间隔，这会阻止适应并使原本可变的传感器输出均匀化。我们的综合模型揭示了CD对于确保波动运动期间精确的本体感受反馈（我们称之为外部本体感受）的重要作用。动物调节感觉处理与运动动作一致。对斑马鱼的必然放电的研究表明，它在游泳过程中调节侧线的敏感性，以防止传感器适应并保持运动控制所需的高质量反馈。
Animals modulate sensory processing in concert with motor actions. Parallel copies of motor signals, called corollary discharge (CD), prepare the nervous system to process the mixture of externally and self-generated (reafferent) feedback that arises during locomotion. Commonly, CD in the peripheral nervous system cancels reafference to protect sensors and the central nervous system from being fatigued and overwhelmed by self-generated feedback. However, cancellation also limits the feedback that contributes to an animal’s awareness of its body position and motion within the environment, the sense of proprioception. We propose that, rather than cancellation, CD to the fish lateral line organ restructures reafference to maximize proprioceptive information content. Fishes’ undulatory body motions induce reafferent feedback that can encode the body’s instantaneous configuration with respect to fluid flows. We combined experimental and computational analyses of swimming biomechanics and hair cell physiology to develop a neuromechanical model of how fish can track peak body curvature, a key signature of axial undulatory locomotion. Without CD, this computation would be challenged by sensory adaptation, typified by decaying sensitivity and phase distortions with respect to an input stimulus. We find that CD interacts synergistically with sensor polarization to sharpen sensitivity along sensors’ preferred axes. The sharpening of sensitivity regulates spiking to a narrow interval coinciding with peak reafferent stimulation, which prevents adaptation and homogenizes the otherwise variable sensor output. Our integrative model reveals a vital role of CD for ensuring precise proprioceptive feedback during undulatory locomotion, which we term external proprioception. Animals modulate sensory processing in concert with motor actions. A study of the corollary discharge in zebrafish reveals that it modulates the sensitivity of the lateral line during swimming to prevent sensor adaptation and maintain the high-quality feedback necessary for kinematic control.
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DOI：
10.1007/2506_2013_15
发表时间：
2014-01-01
期刊：
LATERAL LINE SYSTEM
影响因子：
--
作者：
Chagnaud, Boris Philippe;Coombs, Sheryl
通讯作者：
Coombs, Sheryl
影响因子：
5.5
作者：
FLOCK, A;RUSSELL, IJ
通讯作者：
RUSSELL, IJ
DOI：
10.1098/rspb.2004.2867
发表时间：
2004-10-22
影响因子：
4.7
作者：
de Perera, TB
通讯作者：
de Perera, TB
影响因子：
2.5
作者：
Haehnel, Melanie;Taguchi, Masashige;Liao, James C.
通讯作者：
Liao, James C.
突触可塑性可以产生并增强方向选择性。
影响因子：
4.3
作者：
Carver S;Roth E;Cowan NJ;Fortune ES
通讯作者：
Fortune ES