4D modelling for rapid assessment of biventricular function in congenital heart disease.
4D modelling for rapid assessment of biventricular function in congenital heart disease.
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DOI：
10.1007/s10554-017-1236-6
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Young AA
中科院分区：
文献类型：
--
作者：
Gilbert K;Pontre B;Occleshaw CJ;Cowan BR;Suinesiaputra A;Young AA
虽然越来越多的先天性心脏病（CHD）患者由于更好的手术干预而活得更长，但他们需要定期成像来监测心脏性能。需要能够准确评估这些患者的左心室和右心室的心脏功能的强大的临床工具。我们已经开发出方法来快速量化标准心脏MRI检查的4D（3D +时间）双心室功能。有限元模型进行交互式定制患者的图像，使用导点建模。通过使用极模型预测左心室和心外膜的心脏运动，提高了计算效率和建模大变形的能力。此外，通过循环的大变形更准确地建模使用笛卡尔变形惩罚项。该模型被拟合到用户定义的引导点和图像特征，跟踪整个心动周期的位移。我们在60例包括各种先天性心脏病的病例中测试了该方法，并与金标准手动分析显示出良好的相关性，观察者间误差可接受。该算法比标准分析快得多，并显示出作为CHD患者临床工具的前景。
Although more patients with congenital heart disease (CHD) are now living longer due to better surgical interventions, they require regular imaging to monitor cardiac performance. There is a need for robust clinical tools which can accurately assess cardiac function of both the left and right ventricles in these patients. We have developed methods to rapidly quantify 4D (3D + time) biventricular function from standard cardiac MRI examinations. A finite element model was interactively customized to patient images using guide-point modelling. Computational efficiency and ability to model large deformations was improved by predicting cardiac motion for the left ventricle and epicardium with a polar model. In addition, large deformations through the cycle were more accurately modeled using a Cartesian deformation penalty term. The model was fitted to user-defined guide points and image feature tracking displacements throughout the cardiac cycle. We tested the methods in 60 cases comprising a variety of congenital heart diseases and showed good correlation with the gold standard manual analysis, with acceptable inter-observer error. The algorithm was considerably faster than standard analysis and shows promise as a clinical tool for patients with CHD.
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