Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.
Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.
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多巴胺音调的调节会诱导皮质基碱神经节β振荡的频移。
DOI：
10.1038/s41467-021-27375-5
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发表时间：
2021-12-02
影响因子：
16.6
通讯作者：
Bergman H
中科院分区：
文献类型：
--
作者：
Iskhakova L;Rappel P;Deffains M;Fonar G;Marmor O;Paz R;Israel Z;Eitan R;Bergman H
ΒEta振荡活动(人：13-35 赫兹；灵长类：8-24 赫兹)普遍存在于皮质和基底节。对帕金森氏症患者和动物模型的研究表明，随着多巴胺的耗尽，β能力也会增加。然而，振荡功率、频率和多巴胺音调之间的确切关系仍不清楚。我们记录了健康的非人类灵长类动物皮层和基底节的神经活动，同时急性和慢性地上调和下调多巴胺水平。我们评估了帕金森氏症患者在多巴胺张力急性和慢性变化后β振荡的变化。在这里，我们展示了在猴子和人类中，β振荡频率与多巴胺音调强烈地耦合在一起。功率、单个单位和局部场势(LFP)之间的一致性、尖峰-LFP锁相和相位-幅度耦合不受多巴胺水平的系统调节。这些结果表明，β频率是皮层和基底神经节网络病理性振荡的关键特性。多巴胺调幅导致β振荡生理学的改变。在这里，作者表明，贝塔频率，而不是功率，相干，相位锁定，或PAC是单调联系到多巴胺音调，并可能是皮层和基底神经节网络病理性振荡的关键特性。
Βeta oscillatory activity (human: 13–35 Hz; primate: 8–24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson’s disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson’s following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks. Dopamine tone modulation generates changes in beta oscillation physiology. Here the authors show beta frequency, and not power, coherence, phase-locking, or PAC is monotonically linked to dopamine tone and is likely the key property of pathological oscillations in cortical and basal ganglia networks.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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通讯作者：
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