The Placebo Effect on Mood and Behavior: Possible Role of Opioid and Dopamine Modulation of the Hypothalamic-Pituitary-Adrenal System
The Placebo Effect on Mood and Behavior: Possible Role of Opioid and Dopamine Modulation of the Hypothalamic-Pituitary-Adrenal System
复制标题
安慰剂对情绪和行为的影响：阿片类药物和多巴胺调节下丘脑-垂体-肾上腺系统的可能作用
DOI：
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发表时间：
2003
影响因子：
1.8
通讯作者：
L. Sher
中科院分区：
文献类型：
--
作者：
L. Sher
在过去的几十年里，人们对安慰剂效应越来越感兴趣。安慰剂效应与人体控制和维持健康的潜在机制之间的关系尚不清楚。重要的证据表明，内源性阿片样物质和多巴胺参与了安慰剂效应的机制。内源性阿片和多巴胺能系统已被证明对下丘脑-垂体-肾上腺（HPA）轴的功能活动产生影响。下丘脑系统有助于调节情绪和行为。作者认为，阿片和多巴胺对HPA系统的调节是安慰剂效应对情绪和行为的神经生物学机制之一。阐明安慰剂效应的潜在生物学机制和研究安慰剂在临床实践中的应用以改善健康是两项重要且相互关联的任务。未来对安慰剂反应的神经生物学研究可能会产生有趣和重要的结果。
There has been an increasing interest in the placebo effect over the past several decades. The relationship between the placebo effect and the underlying mechanisms of the body that control and maintain health is still not well understood. Significant evidence suggests that endogenous opioids and dopamine are involved in the mechanisms of the placebo effect. The endogenous opioid and dopaminergic systems have been demonstrated to exert effects on the functional activity of the hypothalamic-pituitary-adrenal (HPA) axis. The HPA system contributes to regulation of mood and behavior. The author suggests that opioid and dopamine modulation of the HPA system is one of the neurobiological mechanisms of the placebo effect on mood and behavior. To elucidate the underlying biological mechanisms of placebo effects and to study the use of placebo in clinical practice to improve health are two important and interrelated tasks. Future studies of the neurobiology of the placebo response may yield interesting and important results.
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DOI：
--
发表时间：
1999
期刊：
Alcoholism, clinical and experimental research.
影响因子：
--
作者：
Petrakis,IL;Trevisan,L;D'Souza,C;Gil,R;Krasnicki,S;Webb,E;Heninger,G;Cooney,N;Krystal,JH
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Krystal,JH
影响因子：
158.5
作者：
DEYO, RA;WALSH, NE;RAMAMURTHY, S
通讯作者：
RAMAMURTHY, S
影响因子：
6
作者：
Anthony A. Grace
通讯作者：
Anthony A. Grace
影响因子：
17.7
作者：
Mayberg, HS;Silva, JA;Jerabek, PA
通讯作者：
Jerabek, PA
影响因子：
1.9
作者：
Lupien, SJ;Gillin, CJ;Hauger, RL
通讯作者：
Hauger, RL